公开(公告)号：US20220152154A1

公开(公告)日：2022-05-19

申请号：US17436696

申请日：2020-03-06

Applicant: Amgen Inc.

Inventor： YuMei XIONG ,  Murielle Marie VENIANT ELLISON

IPC: A61K38/18 ,  A61K39/395 ,  A61K38/26 ,  A61K47/68 ,  A61P3/04

Abstract: The present disclosure provides combination therapy with GDF15 molecules. In some embodiments, the GDF15 molecule is a GDF15-Fc fusion, in which a GDF15 region is fused to an Fc region, optionally via a linker. In one embodiment, combination therapy comprises administration of a GDF15 molecule with a GLP-1R agonist. In another embodiment, combination therapy comprises administration of a GDF15 molecule with a GIPR antagonist.

公开(公告)号：US20240327481A1

公开(公告)日：2024-10-03

申请号：US18746427

申请日：2024-06-18

Applicant: AMGEN INC.

Inventor： YuMei XIONG ,  Kenneth William WALKER ,  Murielle Marie VENIANT ELLISON

IPC: C07K14/495 ,  A61K38/00

CPC classification number: C07K14/495 ,  A61K38/00 ,  C07K2319/30

Abstract: GDF15 molecules are provided herein. In some embodiments, the GDF15 molecule is a GDF15-Fc fusion, in which a GDF15 region is fused to an Fc region. In some embodiments, the GDF15 region is fused to the Fc region via a linker. Also, provided herein arr methods for making and using GDF15 molecules.

公开(公告)号：US20230143988A1

公开(公告)日：2023-05-11

申请号：US16620029

申请日：2019-04-08

Applicant: Amgen Inc.

Inventor： YuMei XIONG ,  Kenneth William WALKER ,  Murielle Marie VENIANT ELLISON

IPC: C07K14/495

CPC classification number: C07K14/495 ,  C07K2319/30

Abstract: GDF15 molecules are provided herein. In some embodiments, the GDF15 molecule is a GDF15-Fc fusion, in which a GDF15 region is fused to an Fc region. In some embodiments, the GDF15 region is fused to the Fc region via a linker. Also, provided herein are methods for making and using GDF15 molecules.

公开(公告)号：US20210147500A1

公开(公告)日：2021-05-20

申请号：US17148761

申请日：2021-01-14

Applicant: Amgen Inc.

Inventor： YuMei XIONG ,  Kenneth William WALKER ,  Murielle Marie VENIANT ELLISON

IPC: C07K14/495

Abstract: GDF15 molecules are provided herein. In some embodiments, the GDF15 molecule is a GDF15-Fc fusion, in which a GDF15 region is fused to an Fc region. In some embodiments, the GDF15 region is fused to the Fc region via a linker. Also, provided herein are methods for making and using GDF15 molecules.

公开(公告)号：US20220017584A1

公开(公告)日：2022-01-20

申请号：US17494001

申请日：2021-10-05

Applicant: Amgen Inc.

Inventor： YuMei XIONG ,  Kenneth William WALKER ,  Murielle Marie VENIANT ELLISON

IPC: C07K14/495

Abstract: GDF15 molecules are provided herein. In some embodiments, the GDF15 molecule is a GDF15-Fc fusion, in which a GDF15 region is fused to an Fc region. In some embodiments, the GDF15 region is fused to the Fc region via a linker. Also, provided herein are methods for making and using GDF15 molecules.

公开(公告)号：US20160024196A1

公开(公告)日：2016-01-28

申请号：US14776012

申请日：2014-03-14

Applicant: AMGEN INC.

Inventor： Jiangwen MAJETI ,  YuMei XIONG ,  Wen-Chen YEH ,  Alykhan S. MOTANI ,  Yang LI

IPC: C07K16/18

CPC classification number: C07K16/18 ,  A61K2039/505 ,  C07K2317/14 ,  C07K2317/51 ,  C07K2317/515 ,  C07K2317/565 ,  C07K2317/76 ,  C07K2317/92

Abstract: Methods of treating metabolic diseases and disorders using an antigen binding protein specific for the SFRP5 polypeptide are provided. In various embodiments the metabolic disease or disorder is type 2 diabetes, obesity, dyslipidemia elevated glucose levels, elevated insulin levels and diabetic nephropathy.

Abstract translation: 提供了使用对SFRP5多肽特异的抗原结合蛋白来治疗代谢疾病和病症的方法。 在各种实施方案中，代谢疾病或病症是2型糖尿病，肥胖症，血脂异常升高的葡萄糖水平，升高的胰岛素水平和糖尿病性肾病。