公开(公告)号：US20150266952A1

公开(公告)日：2015-09-24

申请号：US14621072

申请日：2015-02-12

Applicant: AMGEN INC. ,  AMGEN FREMONT INC.

Inventor： William J. BOYLE ,  Francis H. MARTIN ,  Jose R. CORVALAN ,  C. Geoffrey DAVIS

IPC: C07K16/24 ,  A61K45/06 ,  A61K39/395

CPC classification number: C07K16/2875 ,  A61K39/39541 ,  A61K39/3955 ,  A61K45/06 ,  A61K2039/505 ,  A61K2039/507 ,  C07K16/241 ,  C07K2317/21 ,  C07K2317/51 ,  C07K2317/515 ,  C07K2317/54 ,  C07K2317/55 ,  C07K2317/56 ,  C07K2317/622 ,  C07K2317/76 ,  C07K2317/92 ,  A61K2300/00

Abstract: Antibodies that interact with osteoprotegerin ligand (OPGL) are described. Methods of treating osteopenic disorders by administering a pharmaceutically effective amount of antibodies to OPGL are described. Methods of detecting the amount of OPGL in a sample using antibodies to OPGL are described.

Abstract translation: 描述了与骨保护素配体（OPGL）相互作用的抗体。 描述了通过向OPGL施用药学有效量的抗体来治疗骨质疏松症的方法。 描述使用OPGL抗体检测样品中OPGL的量的方法。

公开(公告)号：US20170183417A1

公开(公告)日：2017-06-29

申请号：US15256194

申请日：2016-09-02

Applicant: AMGEN INC. ,  AMGEN FREMONT INC.

Inventor： William J. BOYLE ,  Francis H. MARTIN ,  Jose R. CORVALAN ,  C. Geoffrey DAVIS

IPC: C07K16/28 ,  A61K45/06 ,  A61K39/395

CPC classification number: C07K16/2875 ,  A61K39/39541 ,  A61K39/3955 ,  A61K45/06 ,  A61K2039/505 ,  A61K2039/507 ,  C07K16/241 ,  C07K2317/21 ,  C07K2317/51 ,  C07K2317/515 ,  C07K2317/54 ,  C07K2317/55 ,  C07K2317/56 ,  C07K2317/622 ,  C07K2317/76 ,  C07K2317/92 ,  A61K2300/00

Abstract: Antibodies that interact with osteoprotegerin ligand (OPGL) are described. Methods of treating osteopenic disorders by administering a pharmaceutically effective amount of antibodies to OPGL are described. Methods of detecting the amount of OPGL in a sample using antibodies to OPGL are described.