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公开(公告)号：US09765157B2
公开(公告)日：2017-09-19
申请号：US14815861
申请日：2015-07-31
发明人： Shouhua Xiao , Zheng Pan , Dineli Wickramasinghe , Peter Kufer , Patrick Hoffmann , Tobias Raum , Ralf Lutterbüse , Elisabeth Nahrwold , Claudia Blumel
CPC分类号： C07K16/468 , A61K47/60 , A61K2039/505 , C07K16/28 , C07K16/2809 , C07K16/2896 , C07K16/30 , C07K2317/21 , C07K2317/30 , C07K2317/31 , C07K2317/33 , C07K2317/622 , C07K2317/73 , C07K2319/00
摘要： The present invention provides a bispecific antibody construct comprising a first human binding domain which binds to human CDH19 on the surface of a target cell and a second binding domain which binds a human CD3 on the surface of a T cell. Moreover, the invention provides a polynucleotide encoding the antibody construct, a vector comprising the polynucleotide and a host cell transformed or transfected with the polynucleotide or vector. Furthermore, the invention provides a process for the production of the antibody construct of the invention, a medical use of the antibody construct in the treatment of melanoma, and a kit comprising the antibody construct.
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公开(公告)号：US20180002450A1
公开(公告)日：2018-01-04
申请号：US15673539
申请日：2017-08-10
发明人： Shouhua Xiao , Zheng Pan , Dineli Wickramasinghe , Peter Kufer , Patrick Hoffmann , Tobias Raum , Ralf Lutterbüse , Elisabeth Nahrwold , Claudia Blumel
CPC分类号： C07K16/468 , A61K47/60 , A61K2039/505 , C07K16/28 , C07K16/2809 , C07K16/2896 , C07K16/30 , C07K2317/21 , C07K2317/30 , C07K2317/31 , C07K2317/33 , C07K2317/622 , C07K2317/73 , C07K2319/00
摘要： The present invention provides to a bispecific antibody construct comprising a first human binding domain which binds to human CDH19 on the surface of a target cell and a second binding domain which binds to human CD3 on the surface of a T cell. Moreover, the invention provides a polynucleotide encoding the antibody construct, a vector comprising said polynucleotide and a host cell transformed or transfected with said polynucleotide or vector. Furthermore, the invention provides a process for the production of the antibody construct of the invention, a medical use of said antibody construct and a kit comprising said antibody construct.
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公开(公告)号：US20160032019A1
公开(公告)日：2016-02-04
申请号：US14815861
申请日：2015-07-31
发明人： Shouhua Xiao , Zheng Pan , Dineli Wickramasinghe , Peter Kufer , Patrick Hoffmann , Tobias Raum , Ralf Lutterbüse , Elisabeth Nahrwold , Claudia Blumel
CPC分类号： C07K16/468 , A61K47/60 , A61K2039/505 , C07K16/28 , C07K16/2809 , C07K16/2896 , C07K16/30 , C07K2317/21 , C07K2317/30 , C07K2317/31 , C07K2317/33 , C07K2317/622 , C07K2317/73 , C07K2319/00
摘要： The present invention provides to a bispecific antibody construct comprising a first human binding domain which binds to human CDH19 on the surface of a target cell and a second binding domain which binds to human CD3 on the surface of a T cell. Moreover, the invention provides a polynucleotide encoding the antibody construct, a vector comprising said polynucleotide and a host cell transformed or transfected with said polynucleotide or vector. Furthermore, the invention provides a process for the production of the antibody construct of the invention, a medical use of said antibody construct and a kit comprising said antibody construct.
摘要翻译： 本发明提供了双特异性抗体构建体，其包含与靶细胞表面上的人CDH19结合的第一人结合结构域和与T细胞表面上的人CD3结合的第二结合结构域。 此外，本发明提供编码抗体构建体的多核苷酸，包含所述多核苷酸的载体和用所述多核苷酸或载体转化或转染的宿主细胞。 此外，本发明提供了制备本发明的抗体构建体的方法，所述抗体构建体的医学用途和包含所述抗体构建体的试剂盒。
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