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公开(公告)号：US20190169310A1
公开(公告)日：2019-06-06
申请号：US16020558
申请日：2018-06-27
发明人： Peter Kufer , Tobias Raum , Roman Kischel , Ralf Lutterbüse , Patrick Hoffmann , Doris Rau , Susanne Mangold , Matthias Klinger , Evelyne Schaller , Susanne Hausmann , Petra Fluhr , Carola Steiger
IPC分类号： C07K16/30
摘要： The present invention relates to a bispecific single chain antibody molecule comprising a first binding domain capable of binding to an epitope of human and non-chimpanzee primate CD3 epsilon chain, wherein the epitope is part of an amino acid sequence comprised in the group consisting of SEQ ID NOs. 2, 4, 6, and 8, and a second binding domain capable of binding to prostate-specific membrane antigen (PSMA). The invention also provides nucleic acids encoding said bispecific single chain antibody molecule as well as vectors and host cells and a process for its production. The invention further relates to pharmaceutical compositions comprising said bispecific single chain antibody molecule and medical uses of said bispecific single chain anti-body molecule.
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公开(公告)号：US11472886B2
公开(公告)日：2022-10-18
申请号：US17221707
申请日：2021-04-02
发明人： Peter Kufer , Tobias Raum , Roman Kischel , Ralf Lutterbüse , Patrick Hoffmann , Doris Rau , Susanne Mangold , Matthias Klinger , Evelyne Schaller , Susanne Hausmann , Petra Fluhr , Carola Steiger
摘要： The present invention relates to a bispecific single chain antibody molecule comprising a first binding domain capable of binding to an epitope of human and non-chimpanzee primate CD3 epsilon chain, wherein the epitope is part of an amino acid sequence comprised in the group consisting of SEQ ID NOs. 2, 4, 6, and 8, and a second binding domain capable of binding to prostate-specific membrane antigen (PSMA). The invention also provides nucleic acids encoding said bispecific single chain antibody molecule as well as vectors and host cells and a process for its production. The invention further relates to pharmaceutical compositions comprising said bispecific single chain antibody molecule and medical uses of said bispecific single chain antibody molecule.
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