公开(公告)号：US11274073B2

公开(公告)日：2022-03-15

申请号：US16608841

申请日：2018-05-10

申请人： ANTALGENICS, S.L.

发明人： Isabel Devesa Giner ,  Armando Genazzani ,  Tracey Pirali ,  Asia Fernandez Carvajal ,  Antonio Vicente Ferrer Montiel

IPC分类号： C07C235/08 ,  C07C231/06 ,  A61P29/00 ,  A61P17/04

摘要： The present invention relates to TRPV1 modulator compounds of formula (I) or their pharmaceutically, veterinary or cosmetically acceptable salts, or their stereoisomers or mixtures thereof, wherein m is an integer selected from 1 to 3; R1, R2, R6 and R6′ are independently selected from H, (C1-C8)alkyl, unsaturated (C2-C8)hydrocarbon, and (C3-C6)cycloalkyl, being these groups optionally substituted; R3 is hydrogen or halogen; R4 is selected from H, (C1-C8)alkyl, unsaturated (C2-C8)hydrocarbon, (C3-C6)cycloalkyl, (C6-C12)aryl, and (C5-C12)heteroaryl, being these groups optionally substituted; and R5 is selected from (C3-C28)alkyl, unsaturated (C3-C28)hydrocarbon, (C6-C12)aryl, and (C5-C12)heteroaryl, being these groups optionally substituted. It also relates to a process for their preparation, to pharmaceutical, veterinary or cosmetic compositions containing them, and to their pharmaceutical, veterinary and cosmetic applications.