公开(公告)号：US20230230234A1

公开(公告)日：2023-07-20

申请号：US18096835

申请日：2023-01-13

Applicant: APPLIED MATERIALS, INC.

Inventor： Sumit Kumar Jha ,  Dan Xie ,  Arina Nikitina ,  Debjit Ray ,  Yun-Ching Chang ,  Suraj Rengarajan

IPC: G06T7/00 ,  G06T5/00 ,  G06T7/11 ,  G06V10/82 ,  G06V20/70

CPC classification number: G06T7/0012 ,  G06T5/002 ,  G06T7/11 ,  G06V10/82 ,  G06V20/70 ,  G06T2207/30024

Abstract: A system and method of performing deep cell body segmentation on a biological sample is provided. The method includes receiving a first and a second stained image. The first image is processed using a trained machine learned model that outputs locations of a plurality of cell nuclei in the first stained image. Seed points are then determined based on the locations of the plurality of cell nuclei. The second image is then processed using the seed points to determine a plurality of cell membranes using a watershed segmentation. The second image is then post-processed and an output image is produced. The output image is then analyzed and gene sequencing is performed.