公开(公告)号：US20200093772A1

公开(公告)日：2020-03-26

申请号：US16526365

申请日：2019-07-30

申请人： APR APPLIED PHARMA RESEARCH S.A.

发明人： Giorgio Reiner ,  Alberto Reiner ,  Paola Maffei

IPC分类号： A61K31/196 ,  A61P29/00 ,  A61K9/08

摘要： Provided are orally formulations of diclofenac potassium with improved stability in response to cold conditions, and excellent taste and palatability.

公开(公告)号：US11419837B2

公开(公告)日：2022-08-23

申请号：US15303121

申请日：2016-09-27

申请人： APR APPLIED PHARMA RESEARCH S.A.

发明人： Alberto Reiner ,  Giorgio Reiner

IPC分类号： A61K31/198 ,  A61K9/16 ,  A23L33/175 ,  A61K9/00 ,  A61K9/50 ,  A61K31/401 ,  A61K31/405 ,  A61K31/4172 ,  A23L33/15 ,  A61K31/00 ,  A61K9/20 ,  A61K33/00 ,  A21D2/24 ,  A23L33/16 ,  A21D13/80 ,  A61P3/00 ,  A61K9/51

摘要： Methods and formulations of modified release amino acids are provided for the treatment or management of diseases defined by impaired amino acid metabolism, with improved pharmacokinetics, metabolism and utilization.

公开(公告)号：US20200323776A1

公开(公告)日：2020-10-15

申请号：US16716511

申请日：2019-12-17

申请人： APR Applied Pharma Research s.a.

发明人： Giorgio Reiner ,  Alberto Reiner

IPC分类号： A61K9/14 ,  A61K9/16 ,  A61K9/20 ,  A61K9/00 ,  A61K9/08 ,  A61K47/10 ,  A61K31/196 ,  A61K47/14

摘要： Methods and formulations are provided for treating migraine and other acute pain episodes using diclofenac, and formulations of diclofenac that provide both rapid and sustained relief from acute pain. Methods and formulations are also provided for treating symptoms that often accompany migraine and acute pain such as photophobia, phonophobia, nausea and vomiting.

公开(公告)号：US20200069624A1

公开(公告)日：2020-03-05

申请号：US16543437

申请日：2019-08-16

申请人： APR Applied Pharma Research s.a.

发明人： Alberto Reiner ,  Giorgio Reiner

IPC分类号： A61K31/198 ,  A61P3/02 ,  A61K31/4172 ,  A61K31/405 ,  A61K31/401 ,  A61K9/16 ,  A61K9/50 ,  A61K45/06 ,  A61K31/197

摘要： Methods of normalizing amino acid metabolism in subjects on restricted protein diets and supplemental amino acids, using specially formulated amino acids that mimic the absorption and metabolism of naturally occurring proteins, are described.

公开(公告)号：US08927604B2

公开(公告)日：2015-01-06

申请号：US13742871

申请日：2013-01-16

申请人： APR Applied Pharma Research s.a.

发明人： Giorgio Reiner ,  Alberto Reiner

IPC分类号： C07C229/00 ,  A01N37/00 ,  A61K31/185 ,  A61K31/19 ,  A61K9/00 ,  A61K9/08 ,  A61K31/196 ,  A61K47/10

CPC分类号： A61K9/14 ,  A61K9/0095 ,  A61K9/08 ,  A61K9/145 ,  A61K9/1623 ,  A61K9/2013 ,  A61K31/196 ,  A61K47/10 ,  A61K47/14

摘要： Methods and formulations are provided for treating migraine and other acute pain episodes using diclofenac, and formulations of diclofenac that provide both rapid and sustained relief from acute pain. Methods and formulations are also provided for treating symptoms that often accompany migraine and acute pain such as photophobia, phonophobia, nausea and vomiting.

摘要翻译： 提供了使用双氯芬酸治疗偏头痛和其他急性疼痛发作的方法和制剂，以及提供急性疼痛的快速和持续缓解的双氯芬酸制剂。 还提供了用于治疗经常伴有偏头痛和急性疼痛如畏光，恐聋，恶心和呕吐的症状的方法和制剂。

公开(公告)号：US11701335B2

公开(公告)日：2023-07-18

申请号：US16543437

申请日：2019-08-16

申请人： APR Applied Pharma Research s.a.

发明人： Alberto Reiner ,  Giorgio Reiner

IPC分类号： A61K31/401 ,  A61P3/08 ,  A61K31/4172 ,  A61K31/198 ,  A61K31/197 ,  A61K9/00 ,  A61P3/02 ,  A61K9/16 ,  A61K9/50 ,  A61K31/405 ,  A61K45/06

CPC分类号： A61K31/198 ,  A61K9/16 ,  A61K9/5036 ,  A61K9/5047 ,  A61K31/197 ,  A61K31/401 ,  A61K31/405 ,  A61K31/4172 ,  A61K45/06 ,  A61P3/02

摘要： Methods of normalizing amino acid metabolism in subjects on restricted protein diets and supplemental amino acids, using specially formulated amino acids that mimic the absorption and metabolism of naturally occurring proteins, are described.

公开(公告)号：US11123318B2

公开(公告)日：2021-09-21

申请号：US16526365

申请日：2019-07-30

申请人： APR APPLIED PHARMA RESEARCH S.A.

发明人： Giorgio Reiner ,  Alberto Reiner ,  Paola Maffei

IPC分类号： A61K31/196 ,  A61P29/00 ,  A61K9/08

摘要： Provided are orally formulations of diclofenac potassium with improved stability in response to cold conditions, and excellent taste and palatability.

公开(公告)号：US20170319484A1

公开(公告)日：2017-11-09

申请号：US15604479

申请日：2017-05-24

申请人： APR Applied Pharma Research s.a.

发明人： Giorgio Reiner ,  Alberto Reiner

IPC分类号： A61K9/14 ,  A61K47/10 ,  A61K31/196 ,  A61K9/20 ,  A61K9/16 ,  A61K9/08 ,  A61K47/14 ,  A61K9/00

CPC分类号： A61K9/14 ,  A61K9/0095 ,  A61K9/08 ,  A61K9/145 ,  A61K9/1623 ,  A61K9/2013 ,  A61K31/196 ,  A61K47/10 ,  A61K47/14

摘要： Methods and formulations are provided for treating migraine and other acute pain episodes using diclofenac, and formulations of diclofenac that provide both rapid and sustained relief from acute pain. Methods and formulations are also provided for treating symptoms that often accompany migraine and acute pain such as photophobia, phonophobia, nausea and vomiting.

公开(公告)号：US20130245122A1

公开(公告)日：2013-09-19

申请号：US13742871

申请日：2013-01-16

申请人： APR APPLIED PHARMA RESEARCH S.A.

发明人： Giorgio Reiner ,  Alberto Reiner ,  Andreas Meyer

IPC分类号： A61K31/196

CPC分类号： A61K9/14 ,  A61K9/0095 ,  A61K9/08 ,  A61K9/145 ,  A61K9/1623 ,  A61K9/2013 ,  A61K31/196 ,  A61K47/10 ,  A61K47/14

摘要： Methods and formulations are provided for treating migraine and other acute pain episodes using diclofenac, and formulations of diclofenac that provide both rapid and sustained relief from acute pain. Methods and formulations are also provided for treating symptoms that often accompany migraine and acute pain such as photophobia, phonophobia, nausea and vomiting.

公开(公告)号：US11260026B2

公开(公告)日：2022-03-01

申请号：US16713052

申请日：2019-12-13

申请人： APR Applied Pharma Research s.a.

发明人： Alberto Reiner ,  Giorgio Reiner

IPC分类号： A61K9/08 ,  A61K9/00 ,  A61K31/196 ,  A61K47/02 ,  A61K47/26

摘要： Ready to use liquid formulations of diclofenac potassium are disclosed which are particularly well suited for packaging in stick-packs.