公开(公告)号：US20210292768A1

公开(公告)日：2021-09-23

申请号：US17266556

申请日：2019-08-08

Applicant: ARCTURUS THERAPEUTICS, INC.

Inventor： Kiyoshi Tachikawa ,  Padmanabh Chivukula ,  Lily Xu ,  Angel Leu ,  Marciano Sablad ,  Rajesh Mukthavaram ,  Priya Karmali

IPC: C12N15/113 ,  A61P1/16

Abstract: This disclosure encompasses compounds and compositions useful in methods for medical therapy, in general, for inhibiting expression of PDGFRB in a subject. The compounds have a first strand and a second strand, each of the strands being 19-29 monomers in length, the monomers comprising UNA monomers and nucleic acid monomers.