公开(公告)号：US20230059111A1

公开(公告)日：2023-02-23

申请号：US17812576

申请日：2022-07-14

Applicant: ARCTURUS THERAPEUTICS, INC.

Inventor： Pattraranee LIMPHONG ,  Kiyoshi TACHIKAWA ,  Padmanabh CHIVUKULA ,  Daiki MATSUDA ,  Arisa CALE

IPC: C07K14/505 ,  C07K14/745 ,  C07K14/575 ,  C07K14/81 ,  A61K38/48 ,  A61K38/17 ,  A61K38/18 ,  A61K31/7115

Abstract: A range of therapeutic mRNA molecules expressible to provide a target polypeptide or protein. The RNA molecules can contain one or more 5-methoxyuridines and 5-methylcytidines. Further provided are DNA templates, which can be transcribed to provide a target mRNA, and can have altered nucleotides, such as reduced deoxyadenosines. Also provided are processes for making the therapeutic mRNA molecules. The RNA molecules can be translated in vitro or in vivo to provide an active polypeptide or protein. The RNA molecules can be included in a composition used for preventing, treating, or ameliorating at least one symptom of a disease or condition in a subject in need thereof.