公开(公告)号：US20230099879A1

公开(公告)日：2023-03-30

申请号：US17945739

申请日：2022-09-15

申请人： ARIZ Precision Medicine, Inc.

发明人： Lonnie L. BOOKBINDER ,  Narendra K. VAISH ,  Brad J. NILES ,  Jonathan FLYNN ,  Nicole NUNEZ

IPC分类号： C12N15/113 ,  A61P35/00

摘要： Inhibitory RNA molecules that specifically inhibit mammalian RIZ2 expression, with therapeutic effect in cell proliferative diseases, such as cancer.

公开(公告)号：US20220267775A1

公开(公告)日：2022-08-25

申请号：US17571251

申请日：2022-01-07

申请人： ARIZ Precision Medicine, Inc.

发明人： Lonnie L. BOOKBINDER ,  Brad NILE ,  Nicole NUNEZ ,  Nicole HALMAI ,  Narendra K. VAISH

IPC分类号： C12N15/113 ,  A61K45/06 ,  A61K47/02 ,  A61K47/54 ,  A61K47/64

摘要： Pharmaceutical formulations for the treatment of cancer comprising novel siRNAs that downregulate expression of the PRDM oncoprotein gene and inhibit tumor growth. siRNAs designed and selected to destroy PRDM14 mRNA are described. The siRNAs are delivered via one or more targeted drug delivery systems equipped with a tumor-specific targeting ligand that confers specific binding of the nanoparticle with siRNA payload to receptors on the surface of tumor cells.

公开(公告)号：US20240360445A1

公开(公告)日：2024-10-31

申请号：US18643535

申请日：2024-04-23

申请人： ARIZ Precision Medicine, Inc.

发明人： Lonnie L. BOOKBINDER ,  Narendra K. VAISH ,  Brad J. NILES ,  Jonathan FLYNN ,  Nicole NUNEZ

IPC分类号： C12N15/113 ,  A61P35/00

CPC分类号： C12N15/113 ,  A61P35/00 ,  C12N2310/14 ,  C12N2310/16 ,  C12N2310/335

摘要： Inhibitory RNA molecules that specifically inhibit mammalian RIZ2 expression, with therapeutic effect in cell proliferative diseases, such as cancer.