公开(公告)号：US11254713B2

公开(公告)日：2022-02-22

申请号：US15968517

申请日：2018-05-01

Applicant: ARIZONA BOARD OF REGENTS ON BEHALF OF ARIZONA STATE UNIVERSITY

Inventor： Kenneth Roland ,  Amanda M. Tafoya

IPC: C07K14/255 ,  A61K31/7115 ,  A61K39/112 ,  A61K39/00

Abstract: In certain embodiments, a recombinant attenuated derivative of a pathogenic Salmonella enterica serovar typhi cell is provided, (a) wherein one or more genes encoding subunits of a stg operon (Salmonella typhi Δstg) are inactivated or deleted resulting in a decrease of Stg adhesin/fimbriae production as compared to genes encoding a wild-type Stg operon (stgABCC′D), and/or (b) the cell comprises a nucleic acid encoding at least one of a gene encoding a subunit of a long polar fimbriae (Lpf) of S. enterica serovar Typhimurium protein. In certain embodiments, vaccines and compositions, and methods of use of the recombinant attenuated derivative of a pathogenic Salmonella enterica serovar typhi cell are provided.

公开(公告)号：US20180312550A1

公开(公告)日：2018-11-01

申请号：US15968517

申请日：2018-05-01

Applicant: Arizona Board Of Regents On Behalf Of Arizona State University

Inventor： Kenneth Roland ,  Amanda M. Tafoya

IPC: C07K14/255 ,  A61K39/112

Abstract: In certain embodiments, the present invention provides a recombinant Salmonella enterica serovar Typhi cell, vaccines and compositions, and methods of use thereof.