公开(公告)号：US20190256616A1

公开(公告)日：2019-08-22

申请号：US16155972

申请日：2018-10-10

Applicant: ARIZONA BOARD OF REGENTS ON BEHALF OF ARIZONA STATE UNIVERSITY

Inventor： Peiming Zhang ,  Xu Wang ,  Jong One Im ,  Stuart Lindsay

IPC: C08B37/00 ,  G16B40/10 ,  G16B40/20 ,  G06N3/08 ,  G06N20/10

Abstract: The present disclosure provides a method for identifying and quantifying sulfated glycosaminoglycans, including for example heparin, by passing a sample through nanopores. The glycosaminoglycans sample is measured in microliter quantities, at nanomolar concentrations with detection of impurities below 0.5%, and a dynamic range over five decades of magnitude with a trained machine learning algorithm.

公开(公告)号：US11325987B2

公开(公告)日：2022-05-10

申请号：US16155972

申请日：2018-10-10

Applicant: ARIZONA BOARD OF REGENTS ON BEHALF OF ARIZONA STATE UNIVERSITY

Inventor： Peiming Zhang ,  Xu Wang ,  Jong One Im ,  Stuart Lindsay

IPC: G01N33/48 ,  G01N33/50 ,  C08B37/00 ,  G06N20/10 ,  G16B40/20 ,  G06N3/08 ,  G16B40/10

Abstract: The present disclosure provides a method for identifying and quantifying sulfated glycosaminoglycans, including for example heparin, by passing a sample through nanopores. The glycosaminoglycans sample is measured in microliter quantities, at nanomolar concentrations with detection of impurities below 0.5%, and a dynamic range over five decades of magnitude with a trained machine learning algorithm.