公开(公告)号：US20190032134A1

公开(公告)日：2019-01-31

申请号：US16061591

申请日：2017-01-10

申请人： ARMO BioSciences, Inc.

发明人： John Brian Mumm ,  Ivan Ho Chan ,  Scott McCauley ,  Scott Ogg ,  Martin Oft

IPC分类号： C12Q1/6881 ,  C07K14/725 ,  C12N5/0783 ,  A61K35/17 ,  A61K38/20 ,  A61K45/06 ,  A61P35/00 ,  A61K47/60

摘要： The present disclosure provides methods and compositions relating to isolated CD8+ T cells expressing a disease antigen-specific T cell receptor, as well as nucleic acids encoding the Vα and Vβ polypeptide pairs of T cell receptors (TCRs) of such disease antigen-specific T cells. Such disease antigen-specific CD8+ T cells are obtainable from the periphery (e.g., blood) of a subject having a disease amenable to treatment with an IL-10 agent. The present disclosure also contemplates therapeutic methods and compositions relating to administration of isolated disease antigen-specific CD8+ T cells to a subject, as well as therapeutic methods and compositions relating to CD8+ T cells genetically modified to express a disease antigen-specific TCR and/or chimeric antigen receptor.

公开(公告)号：US20180333464A1

公开(公告)日：2018-11-22

申请号：US15986486

申请日：2018-05-22

申请人： ARMO BioSciences, Inc.

发明人： John Brian Mumm ,  Ivan Ho Chan

IPC分类号： A61K38/20 ,  A61K31/455 ,  A61K31/397 ,  A61K45/06

CPC分类号： A61K38/2066 ,  A61K31/397 ,  A61K31/455 ,  A61K45/06 ,  C07K2319/00 ,  A61K2300/00

摘要： Methods of treating subjects having diseases, disorders, or conditions, including disorders associated with cholesterol homeostasis, responsive to IL-10, including methods of administration and dosing regimens associated therewith, are provided.

公开(公告)号：US20180360977A1

公开(公告)日：2018-12-20

申请号：US16060389

申请日：2016-12-15

申请人： ARMO BioSciences, Inc.

发明人： Scott Alan McCauley ,  John Brian Mumm ,  Ivan Ho Chan

IPC分类号： A61K47/60 ,  A61K38/20 ,  A61K9/00

摘要： Pegylated interleukin-15—related molecules and the identification thereof are described. The pegylated interleukin-15 molecules exhibit properties and characteristics that make them candidates for therapeutic use. Pharmaceutical compositions and methods of use are also described herein. 1C. Mature human IL-15 Protein NWVNVISDLKKIEDLIQSMHIDATLYTESDVHPSCKVTAMKCFLLELQVI SLESGDASIHDTVENLIILANNSLSSNGNVTESGCKECEELEEKNIKEFL QSFVHIVQMFINTS

公开(公告)号：US20180207270A1

公开(公告)日：2018-07-26

申请号：US15926118

申请日：2018-03-20

申请人： ARMO BioSciences, Inc.

发明人： John Brian Mumm ,  Ivan Ho Chan

IPC分类号： A61K39/395 ,  C07K14/725 ,  A61K9/00 ,  A61K38/20 ,  A61K39/39 ,  A61K47/60 ,  C07K16/30 ,  C12N15/113 ,  A61K39/00

CPC分类号： A61K39/39558 ,  A61K9/0019 ,  A61K38/2066 ,  A61K39/39 ,  A61K47/60 ,  A61K2039/5158 ,  A61K2039/55527 ,  C07K14/7051 ,  C07K16/30 ,  C07K2317/73 ,  C07K2319/02 ,  C07K2319/03 ,  C12N15/1136 ,  C12N2310/14

摘要： Methods of modulating immune responses in subjects having oncology- and immune-related diseases, disorders and conditions by the administration of an IL-10 agent, including pegylated IL-10.

公开(公告)号：US20160361415A1

公开(公告)日：2016-12-15

申请号：US15165918

申请日：2016-05-26

申请人： ARMO BioSciences, Inc.

发明人： John Brian Mumm ,  Ivan Ho Chan

IPC分类号： A61K39/395 ,  A61K38/20 ,  C12N15/113 ,  A61K9/00 ,  C07K16/30 ,  C07K14/725 ,  A61K47/48

CPC分类号： A61K39/39558 ,  A61K9/0019 ,  A61K38/2066 ,  A61K39/39 ,  A61K47/60 ,  A61K2039/5158 ,  A61K2039/55527 ,  C07K14/7051 ,  C07K16/30 ,  C07K2317/73 ,  C07K2319/02 ,  C07K2319/03 ,  C12N15/1136 ,  C12N2310/14

摘要： Methods of modulating immune responses in subjects having oncology- and immune-related diseases, disorders and conditions by the administration of an IL-10 agent, including pegylated IL-10.

摘要翻译： 通过施用IL-10剂（包括聚乙二醇化的IL-10）调节具有肿瘤学和免疫相关疾病，病症和病症的受试者的免疫应答的方法。

公开(公告)号：US20160243196A1

公开(公告)日：2016-08-25

申请号：US15031651

申请日：2014-11-07

申请人： ARMO BIOSCIENCES, INC.

发明人： John Brian Mumm ,  Ivan Ho Chan ,  Martin Oft

IPC分类号： A61K38/20 ,  A61K9/08 ,  A61K9/00 ,  A61K45/06 ,  A61K39/395 ,  A61K47/48

CPC分类号： A61K38/2066 ,  A61K9/0019 ,  A61K39/395 ,  A61K39/3955 ,  A61K45/06 ,  A61K47/10 ,  A61K47/60 ,  A61K2300/00

摘要： Methods of treating subjects having diseases, disorders, or conditions, including cancer and immune- and inflammatory-related disorders, via the administration of IL-10 in combination with one or more additional agents, and methods and models associated therewith, are provided.

摘要翻译： 提供了通过与一种或多种另外的试剂组合施用IL-10，以及与之相关的方法和模型来治疗患有疾病，病症或病症（包括癌症和免疫和炎性相关疾病）的受试者的方法。

公开(公告)号：US10398761B2

公开(公告)日：2019-09-03

申请号：US15751134

申请日：2016-08-24

申请人： ARMO BioSciences, Inc.

发明人： John Brian Mumm ,  Ivan Ho Chan

IPC分类号： A61K38/20 ,  A61K45/06 ,  A61K33/24 ,  A61K47/60 ,  A61P35/00 ,  A61K9/00

摘要： Methods of treating subjects having a cancer-related disease, disorder, or condition, or preventing the occurrence of such a disease, disorder or condition, via the administration of a PEG-IL-10 agent in combination with an IL-15 agent are provided.

公开(公告)号：US10293043B2

公开(公告)日：2019-05-21

申请号：US15313465

申请日：2015-05-06

申请人： ARMO BioSciences, Inc.

发明人： John Brian Mumm ,  Ivan Ho Chan

IPC分类号： C12Q1/60 ,  C07K14/47 ,  A61K38/00 ,  A61K38/17 ,  A61K38/20 ,  G01N33/50 ,  A61K39/385 ,  A61K49/00 ,  C07K14/715 ,  C07K17/02 ,  A61K47/60 ,  G01N33/92 ,  A61K48/00

摘要： Methods of treating subjects having diseases, disorders, or conditions, including disorders associated with cholesterol homeostasis, responsive to agents modulating Kupffer cell function, including methods of administration and dosing regimens associated therewith, are provided. Methods of treating subjects having liver diseases, disorders, or conditions, including non-alcoholic steatohepatitis and non-alcoholic fatty liver disease, with an IL-10 agent are also provided.

公开(公告)号：US10010588B2

公开(公告)日：2018-07-03

申请号：US14908992

申请日：2014-08-26

申请人： ARMO BioSciences, Inc.

发明人： John Brian Mumm ,  Ivan Ho Chan

IPC分类号： A61K38/20 ,  A61K45/06 ,  A61K31/397 ,  A61K31/455

CPC分类号： A61K38/2066 ,  A61K31/397 ,  A61K31/455 ,  A61K45/06 ,  C07K2319/00 ,  A61K2300/00

摘要： Methods of treating subjects having diseases, disorders, or conditions, including disorders associated with cholesterol homeostasis, responsive to IL-10, including methods of administration and dosing regimens associated therewith, are provided, More particularly, the present disclosure relates to optimized dosing parameters to achieve and maintain efficacy in the treatment and/or prevention of metabolic diseases, disorders and conditions in a subject, while minimizing the adverse effects associated therewith. Particular embodiments are directed to the treatment and/or prevention of abnormally high levels of cholesterol and/or manifestation(s) of hypercholesterolemia in as subject.

公开(公告)号：US20180002434A1

公开(公告)日：2018-01-04

申请号：US15543949

申请日：2016-02-01

申请人： ARMO BioSciences, Inc.

发明人： John Brian Mumm ,  Ivan Ho Chan

IPC分类号： C07K16/28 ,  A61K38/20 ,  A61K39/395

CPC分类号： C07K16/2887 ,  A61K38/2066 ,  A61K39/39558 ,  C07K2317/732 ,  A61K2300/00

摘要： Methods of treating subjects having a proliferative disease, disorder, or condition, including cancer, via the administration of an IL-10 agent, including pegylated IL-10, in combination with an antibody capable of inducing anti-body-dependent cell-mediated cytotoxicity, are provided.