公开(公告)号：US20150147746A1

公开(公告)日：2015-05-28

申请号：US14090298

申请日：2013-11-26

Applicant: ASPECT IMAGING LTD.

Inventor： Uri RAPOPORT ,  Camilla CAVALLOTTI ,  Simonetta GENINATTI CRICH

IPC: G01N27/74

CPC classification number: G01N27/745 ,  A61B5/05 ,  G01N24/088 ,  G01R33/1269 ,  G01R33/1276 ,  G01R33/281

Abstract: A method of detecting a target biochemical molecular species or at least one property correlated with the occurrence of the biochemical molecular species in a sample whose main component is water. The method includes: obtaining a sample whose main component is water; providing Functionalized Paramagnetic Particles (FPP) including a paramagnetic core and a moiety configured to interact with the target biochemical molecular species or with molecules collectively reporting on a property of the target biochemical molecular species; contacting the FPP with the sample; exposing the sample to an applied magnetic field; measuring a change in a nuclear relaxation property of the sample; and correlating the change to the presence of the biochemical molecular species in the sample or to at least one property correlated with the occurrence of the biochemical molecular species in the sample.

Abstract translation: 一种检测目标生化分子种类或与主要成分为水的样品中与生化分子种类的发生相关的至少一种性质的方法。 该方法包括：获得主要成分为水的样品; 提供功能性顺磁性颗粒（FPP），其包括顺磁性核和被配置成与靶生物化学分子物质相互作用的部分，或与共同报告靶生物化学分子种类的性质的分子相结合; 将FPP与样品接触; 将样品暴露于施加的磁场; 测量样品的核松弛性质的变化; 并将该变化与样品中生化分子物质的存在相关联，或与样品中生化分子物质的发生相关的至少一种性质相关联。

公开(公告)号：US20170023526A1

公开(公告)日：2017-01-26

申请号：US15286255

申请日：2016-10-05

Applicant: ASPECT IMAGING LTD.

Inventor： Uri RAPOPORT ,  Camilla CAVALLOTTI ,  Simonetta GENINATTI CRICH

IPC: G01N27/74 ,  G01R33/28 ,  G01N24/08 ,  G01R33/12

CPC classification number: G01N27/745 ,  A61B5/05 ,  G01N24/088 ,  G01R33/1269 ,  G01R33/1276 ,  G01R33/281

Abstract: The present invention discloses a method and systems for detecting a target biochemical molecular species whose main component is water. In one aspect, the method comprises steps of: (a) obtaining a sample whose main component is water; (b) providing Functionalized Paramagnetic Particles (FPP) comprising a paramagnetic core and a moiety configured to interact with the target biochemical molecular species; (c) contacting the FPP with the sample; (d) exposing the sample to an applied magnetic field; (e) measuring a change in a nuclear relaxation property of the sample, caused by the interaction between the FPP and the biochemical molecular species in the applied magnetic field; and (f) correlating the change to the presence of the biochemical molecular species in the sample. According to a main aspect of the invention, a change in T.sub.1 nuclear relaxation property of the water protons in the sample is correlated to the presence of the target biochemical molecular species.

Abstract translation: 本发明公开了一种检测主要成分为水的目标生化分子种类的方法和系统。 一方面，该方法包括以下步骤：（a）获得主要成分为水的样品; （b）提供功能性顺磁性颗粒（FPP），其包含顺磁性核和被配置为与靶生物化学分子物质相互作用的部分; （c）将FPP与样品接触; （d）将样品暴露于所施加的磁场; （e）由施加磁场中的FPP与生化分子种类之间的相互作用引起的测量样品的核弛豫性质的变化; 和（f）将变化与样品中生化分子种类的存在相关联。 根据本发明的主要方面，样品中水质子的T.松弛性质的变化与目标生化分子种类的存在相关。