-
公开(公告)号：US20230278989A1
公开(公告)日：2023-09-07
申请号：US18159452
申请日：2023-01-25
发明人： Steven HOWARD , Benjamin David CONS , Jeffrey David ST. DENIS , Charlotte Mary GRIFFITHS-JONES , Steven Douglas HISCOCK , Rhian Sara HOLVEY , Alan Richard BURNS , David COUSIN , Hannah Louise DEXTER , Guillaume François PARRA , John Paul WATTS , Robert JEWELL , Jennifer Ann STOCKWELL , Kim Louise HIRST , Isabelle Anne LEMASSON , David John NASH , James Daniel OSBORNE , Jonas Calleja PRIEDE , Nicholas Paul RICHARDS , Aaron Michael DUMAS , Brian Christopher BISHOP , David PARRY-JONES , Jeremy Peter SCOTT , Meenakshi Sundaram SHANMUGHAM , Peter Richard MULLENS , David Charles LATHBURY , Darren James DIXON , Matthew James GAUNT
IPC分类号： C07D405/06
CPC分类号： C07D405/06 , C07B2200/13
摘要： The invention relates to processes for preparing isoindolin-1-one derivatives, and in particular processes for preparing (2S,3S)-3-(4-chlorophenyl)-3-[(1R)-1-(4-chlorophenyl)-7-fluoro-5-[(1S)-1-hydroxy-1-(oxan-4-yl)propyl]-1-methoxy-3-oxo-2,3-dihydro-1H-isoindol-2-yl]-2-methylpropanoic acid. The invention also relates to crystalline forms of the compound (2S,3S)-3-(4-chlorophenyl)-3-[(1R)-1-(4-chlorophenyl)-7-fluoro-5-[(1S)-1-hydroxy-1-(oxan-4-yl)propyl]-1-methoxy-3-oxo-2,3-dihydro-1H-isoindol-2-yl]-2-methylpropanoic acid and its salts.
-
公开(公告)号：US20210101887A1
公开(公告)日：2021-04-08
申请号：US16498207
申请日：2018-03-28
发明人： Steven HOWARD , Benjamin David CONS , Jeffrey David ST. DENIS , Charlotte Mary GRIFFITHS-JONES , Steven Douglas HISCOCK , Rhian Sara HOLVEY , Alan Richard BURNS , David COUSIN , Hannah Louise DEXTER , Guillaume François PARRA , John Paul WATTS , Robert JEWELL , Jennifer Ann STOCKWELL , Kim Louise HIRST , Isabelle Anne LEMASSON , David John NASH , James Daniel OSBORNE , Jonas Calleja PRIEDE , Nicholas Paul RICHARDS , Aaron Michael DUMAS , Brian Christopher BISHOP , David PARRY-JONES , Jeremy Peter SCOTT , Meenakshi Sundaram SHANMUGHAM , Peter Richard MULLENS , David Charles LATHBURY , Darren James DIXON , Matthew James GAUNT
IPC分类号： C07D405/06
摘要： The invention relates to processes for preparing isoindolin-1-one derivatives, and in particular processes for preparing (2S,3S)-3-(4-chlorophenyl)-3-[(1R)-1-(4-chlorophenyl)-7-fluoro-5-[(1S)-1-hydroxy-1-(oxan-4-yl)propyl]-1-methoxy-3-oxo-2,3-dihydro-1H-isoindol-2-yl]-2-methylpropanoic acid. The invention also relates to crystalline forms of the compound (2S,3S)-3-(4-chlorophenyl)-3-[(1R)-1-(4-chlorophenyl)-7-fluoro-5-[(1S)-1-hydroxy-1-(oxan-4-yl)propyl]-1-methoxy-3-oxo-2,3-dihydro-1H-isoindol-2-yl]-2-methylpropanoic acid and its salts.
-
搜索结果
2 条记录 (耗时 0.015 秒)
