公开(公告)号：US20230030983A1

公开(公告)日：2023-02-02

申请号：US17655519

申请日：2022-03-18

Applicant: ASTEX THERAPEUTICS LTD

Inventor： Jayaprakash KARKERA ,  Suso Jesus PLATERO ,  Raluca VERONA ,  Matthew V. LORENZI

IPC: A61K39/395 ,  G01N33/574 ,  A61K31/498 ,  C12Q1/6886 ,  A61K45/06 ,  C07K16/28

Abstract: Provided herein are combination therapies for the treatment of cancer. In particular, the disclosed methods are directed to treatment of cancer in a patient comprising administering an antibody that blocks the interaction between PD-1 and PD-L1 and an FGFR inhibitor, wherein the antibody that blocks the interaction between PD-1 and PD-L1 and the FGFR inhibitor are administered if one or more FGFR variants are present in a biological sample from the patient.