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公开(公告)号：US20240041834A1
公开(公告)日：2024-02-08
申请号：US18484334
申请日：2023-10-10
Applicant: ASTRAZENECA AB , Array BioPharma, Inc.
Inventor： Nicola Frances BATEMAN , Paul Richard GELLERT , Kathryn Jane HILL
IPC: A61K31/4184 , A61K9/14 , A61K9/48 , C07D235/06 , A61K47/36 , A61K9/00 , A61K47/22
CPC classification number: A61K31/4184 , A61K9/145 , A61K9/146 , A61K9/4858 , A61K9/4866 , C07D235/06 , A61K47/36 , A61K9/0053 , A61K47/22
Abstract: The invention concerns pharmaceutical compositions containing a hydrogen sulphate salt of 6-(4-bromo-2-chloro-phenylamino)-7-fluoro-3-methyl-3H-benzoimidazole-5-carboxylic acid (2-hydroxy-ethoxy)-amide and solvates, crystalline forms and amorphous forms thereof, to the use of said compositions as a medicament; and to processes for the preparation of said compositions.
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公开(公告)号：US20240423960A1
公开(公告)日：2024-12-26
申请号：US18823257
申请日：2024-09-03
Applicant: ASTRAZENECA AB , Array BioPharma, Inc.
Inventor： Nicola Frances BATEMAN , Paul Richard GELLERT , Kathryn Jane HILL
IPC: A61K31/4184 , A61K9/00 , A61K9/14 , A61K9/48 , A61K47/22 , A61K47/36 , C07D235/06
Abstract: The invention concerns pharmaceutical compositions containing a hydrogen sulphate salt of 6-(4-bromo-2-chloro-phenylamino)-7-fluoro-3-methyl-3H-benzoimidazole-5-carboxylic acid (2-hydroxy-ethoxy)-amide and solvates, crystalline forms and amorphous forms thereof, to the use of said compositions as a medicament, and to processes for the preparation of said compositions.
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公开(公告)号：US20160030574A1
公开(公告)日：2016-02-04
申请号：US14884343
申请日：2015-10-15
Applicant: AstraZeneca AB , Array BioPharma, Inc.
Inventor： Nicola Frances BATEMAN , Paul Richard GELLERT , Kathryn Jane HILL
IPC: A61K47/22 , A61K9/48 , A61K9/14 , A61K31/4184 , A61K9/00
CPC classification number: A61K31/4184 , A61K9/0053 , A61K9/145 , A61K9/146 , A61K9/4858 , A61K9/4866 , A61K47/22 , A61K47/36 , C07D235/06
Abstract: The invention concerns pharmaceutical compositions containing a hydrogen sulphate salt of 6-(4-bromo-2-chloro-phenylamino)-7-fluoro-3-methyl-3H-benzoimidazole-5-carboxylic acid (2-hydroxy-ethoxy)-amide and solvates, crystalline forms and amorphous forms thereof, to the use of said compositions as a medicament; and to processes for the preparation of said compositions.
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公开(公告)号：US20220087982A1
公开(公告)日：2022-03-24
申请号：US17313312
申请日：2021-05-06
Applicant: AstraZeneca AB , Array BioPharma, Inc.
Inventor： Nicola Frances BATEMAN , Paul Richard GELLERT , Kathryn Jane HILL
IPC: A61K31/4184 , A61K9/14 , A61K9/48 , C07D235/06 , A61K47/36 , A61K9/00 , A61K47/22
Abstract: The invention concerns pharmaceutical compositions containing a hydrogen sulphate salt of 6-(4-bromo-2-chloro-phenylamino)-7-fluoro-3-methyl-3H-benzoimidazole-5-carboxylic acid (2-hydroxy-ethoxy)-amide and solvates, crystalline forms and amorphous forms thereof, to the use of said compositions as a medicament; and to processes for the preparation of said compositions.
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公开(公告)号：US20190030004A1
公开(公告)日：2019-01-31
申请号：US16023102
申请日：2018-06-29
Applicant: AstraZeneca AB , Array BioPharma, Inc.
Inventor： Nicola Frances BATEMAN , Paul Richard GELLERT , Kathryn Jane HILL
IPC: A61K31/4184 , C07D235/06 , A61K9/14 , A61K9/48 , A61K47/36 , A61K9/00 , A61K47/22
Abstract: The invention concerns pharmaceutical compositions containing a hydrogen sulphate salt of 6-(4-bromo-2-chloro-phenylamino)-7-fluoro-3-methyl-3H-benzoimidazole-5-carboxylic acid (2-hydroxy-ethoxy)-amide and solvates, crystalline forms and amorphous forms thereof, to the use of said compositions as a medicament; and to processes for the preparation of said compositions.
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Patent Agency Ranking
公开(公告)号：US20240041835A1
公开(公告)日：2024-02-08
申请号：US18484337
申请日：2023-10-10
Applicant: ASTRAZENECA AB , Array BioPharma, Inc.
Inventor： Nicola Frances BATEMAN , Paul Richard GELLERT , Kathryn Jane HILL
IPC: A61K31/4184 , A61K9/14 , A61K9/48 , C07D235/06 , A61K47/36 , A61K9/00 , A61K47/22
CPC classification number: A61K31/4184 , A61K9/145 , A61K9/146 , A61K9/4858 , A61K9/4866 , C07D235/06 , A61K47/36 , A61K9/0053 , A61K47/22
Abstract: The invention concerns pharmaceutical compositions containing a hydrogen sulphate salt of 6-(4-bromo-2-chloro-phenylamino)-7-fluoro-3-methyl-3H-benzoimidazole-5-carboxylic acid (2-hydroxy-ethoxy)-amide and solvates, crystalline forms and amorphous forms thereof, to the use of said compositions as a medicament; and to processes for the preparation of said compositions.
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公开(公告)号：US20130195971A1
公开(公告)日：2013-08-01
申请号：US13747853
申请日：2013-01-23
Applicant: AstraZeneca AB , Array BioPharma, Inc.
Inventor： Nicola Frances BATEMAN , Paul Richard GELLERT , Kathryn Jane HILL
IPC: A61K47/36
CPC classification number: A61K31/4184 , A61K9/0053 , A61K9/145 , A61K9/146 , A61K9/4858 , A61K9/4866 , A61K47/22 , A61K47/36 , C07D235/06
Abstract: The invention concerns pharmaceutical compositions containing a hydrogen sulphate salt of 6-(4-bromo-2-chloro-phenylamino)-7-fluoro-3-methyl-3H-benzoimidazole-5-carboxylic acid (2-hydroxy-ethoxy)-amide and solvates, crystalline forms and amorphous forms thereof, to the use of said compositions as a medicament; and to processes for the preparation of said compositions.
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公开(公告)号：US20250000848A1
公开(公告)日：2025-01-02
申请号：US18823274
申请日：2024-09-03
Applicant: ASTRAZENECA AB , Array BioPharma, Inc.
Inventor： Nicola Frances BATEMAN , Paul Richard GELLERT , Kathryn Jane HILL
IPC: A61K31/4184 , A61K9/00 , A61K9/14 , A61K9/48 , A61K47/22 , A61K47/36 , C07D235/06
Abstract: The invention concerns pharmaceutical compositions containing a hydrogen sulphate salt of 6-(4-bromo-2-chloro-phenylamino)-7-fluoro-3-methyl-3H-benzoimidazole-5-carboxylic acid (2-hydroxy-ethoxy)-amide and solvates, crystalline forms and amorphous forms thereof, to the use of said compositions as a medicament, and to processes for the preparation of said compositions.
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公开(公告)号：US20200179344A1
公开(公告)日：2020-06-11
申请号：US16597237
申请日：2019-10-09
Applicant: AstraZeneca AB , Array BioPharma, Inc.
Inventor： Nicola Frances BATEMAN , Paul Richard GELLERT , Kathryn Jane HILL
IPC: A61K31/4184 , A61K47/22 , A61K9/00 , A61K47/36 , C07D235/06 , A61K9/48 , A61K9/14
Abstract: The invention concerns pharmaceutical compositions containing a hydrogen sulphate salt of 6-(4-bromo-2-chloro-phenylamino)-7-fluoro-3-methyl-3H-benzoimidazole-5-carboxylic acid (2-hydroxy-ethoxy)-amide and solvates, crystalline forms and amorphous forms thereof, to the use of said compositions as a medicament; and to processes for the preparation of said compositions.
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公开(公告)号：US20170056375A1
公开(公告)日：2017-03-02
申请号：US15348053
申请日：2016-11-10
Applicant: AstraZeneca AB , Array BioPharma, Inc.
Inventor： Nicola Frances BATEMAN , Paul Richard GELLERT , Kathryn Jane HILL
CPC classification number: A61K31/4184 , A61K9/0053 , A61K9/145 , A61K9/146 , A61K9/4858 , A61K9/4866 , A61K47/22 , A61K47/36 , C07D235/06
Abstract: The invention concerns pharmaceutical compositions containing a hydrogen sulphate salt of 6-(4-bromo-2-chloro-phenylamino)-7-fluoro-3-methyl-3H-benzoimidazole-5-carboxylic acid (2-hydroxy-ethoxy)-amide and solvates, crystalline forms and amorphous forms thereof, to the use of said compositions as a medicament; and to processes for the preparation of said compositions.
Abstract translation: 本发明涉及含有6-（4-溴-2-氯 - 苯基氨基）-7-氟-3-甲基-3H-苯并咪唑-5-羧酸（2-羟基 - 乙氧基） - 酰胺的硫酸氢盐的药物组合物 并使用所述组合物作为药物溶剂化其结晶形式和无定形形式; 以及制备所述组合物的方法。
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