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公开(公告)号：US20240035003A1
公开(公告)日：2024-02-01
申请号：US18256484
申请日：2021-12-10
发明人： JINLIN JIANG , NICOLE BLECKWENN , RAGHAVAN VENKAT , DANIEL PAPPAS , BENJAMIN RUSH , GEORGE CHACKO
IPC分类号： C12N7/02 , C12N15/86 , A61K39/215
CPC分类号： C12N7/02 , C12N15/86 , A61K39/215 , A61K2039/5254
摘要： Methods for the production of adenoviruses which are suitable for use in a vaccine, and methods for increasing the yield of adenoviruses during production. These methods include adding an adenovirus to a cell population in culture; culturing the cell population under conditions which are permissive for infection of the cell population with the adenovirus to provide a cell population comprising adenovirus-infected cells; culturing the cell population comprising adenovirus-infected cells under conditions which are permissive for replication of the adenovirus; and harvesting the adenovirus from the culture.
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公开(公告)号：US20220184156A1
公开(公告)日：2022-06-16
申请号：US17547323
申请日：2021-12-10
发明人： JINLIN JIANG , NICOLE BLECKWENN , RAGHAVAN VENKAT , DANIEL PAPPAS , BENJAMIN RUSH , GEORGE CHACKO
IPC分类号： A61K35/761 , C12N7/00 , A61K39/235
摘要： Methods for the production of adenoviruses which are suitable for use in a vaccine, and methods for increasing the yield of adenoviruses during production. These methods include adding an adenovirus to a cell population in culture; culturing the cell population under conditions which are permissive for infection of the cell population with the adenovirus to provide a cell population comprising adenovirus-infected cells; culturing the cell population comprising adenovirus-infected cells under conditions which are permissive for replication of the adenovirus; and harvesting the adenovirus from the culture.
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