公开(公告)号：US12121615B2

公开(公告)日：2024-10-22

申请号：US17267541

申请日：2020-01-08

申请人： ATLANGRAM

发明人： Olivier Meyer ,  Amokrane Reghal

IPC分类号： A61K9/51 ,  A61K38/12 ,  A61P19/00 ,  A61P31/04

CPC分类号： A61K9/5123 ,  A61K9/5153 ,  A61K9/5161 ,  A61K38/12 ,  A61P19/00 ,  A61P31/04

摘要： The present invention relates to a pharmaceutical composition stabilized in a gelled state at at least a temperature varying from 15° C. to 40° C., comprising at least one aqueous phase gelled with at least one hydrophilic polymeric gelling agent, lipid nanocapsules comprising a liquid or semi-liquid lipid core at room temperature enveloped in a lipid envelope which is solid at room temperature, said gelled aqueous phase and nanocapsules containing at least one antibiotic, identical or different, the antibiotic in said aqueous phase being present there in the form of a solute.