专利检索 ap:("AURISCO PHARMACEUTICAL CO., LTD.") AND inv:"Xiongpeng DUAN" 第 1 页

1.

发明公开
HIGH-PURITY THIENOPYRIMIDINE COMPOUND AND PREPARATION METHOD THEREFOR 审中-公开

公开(公告)号：US20240317773A1

公开(公告)日：2024-09-26

申请号：US18546049

申请日：2021-09-06

申请人： AURISCO PHARMACEUTICAL CO., LTD.

发明人： Wancheng GUO , Fuchang ZHANG , Yongli DUAN , Xiongpeng DUAN , Guoping WANG

IPC分类号： C07D495/04 , G01N33/15

CPC分类号： C07D495/04 , G01N33/15

摘要： A thienopyrimidine compound (a compound of formula N) and a preparation method therefor are provided. Specifically, the preparation method includes the steps of: (a) in a solvent A, reacting, in the presence of an organic base and acyl chloride, a compound of formula N-2 with 3-amino-6-methoxypyridazine to obtain a compound of formula N-1; and (b) in a solvent B, converting, in the presence of a base, the compound of formula N-1 into the compound of formula N. The preparation method does not require toxic and expensive reagents, has mild reaction conditions and a high product purity, and is suitable for industrial production.