公开(公告)号：US20180194743A1

公开(公告)日：2018-07-12

申请号：US15741859

申请日：2016-05-09

申请人： Sukumar NANDI ,  Shantan Kumar REDDY ,  Gona BALANARASHIMHA REDDY ,  AUROBINDO PHARMA LTD

发明人： Sukumar Nandi ,  Shantan Kumar Reddy ,  Gona Bala Narashimha Reddy ,  Sivakumaran Meenakshisundaram

IPC分类号： C07D277/40

CPC分类号： C07D277/40

摘要： The present invention provides a process for the preparation of α-Form crystals of Mirabegron using a solvent selected from water.

公开(公告)号：US20180194734A1

公开(公告)日：2018-07-12

申请号：US15741722

申请日：2016-03-18

申请人： AUROBINDO PHARMA LTD

发明人： Sukumar Nandi ,  Akkina Naresh ,  Syam Prasad Reddy Rao Annareddy ,  Gona Bala Narsimha Reddy ,  Meenakshi Sunderam Sivakumaran

IPC分类号： C07D223/16

CPC分类号： C07D223/16 ,  C07B2200/13

摘要： The present invention provides a process for the preparation of crystalline Lorcaserin hydrochloride hemihydrate of Formula (1a), which comprises, Formula (1a) (i) providing a solution of Lorcaserin base in a solvent; (ii) if water is present, removing water from the reaction mixture; (iii) adding hydrogen chloride to the reaction mixture; (iv) combining the reaction mixture with a suitable anti-solvent; and (v) isolating the crystalline Lorcaserin hydrochloride hemihydrate of Formula (1a).

公开(公告)号：US10308611B2

公开(公告)日：2019-06-04

申请号：US15741722

申请日：2016-03-18

申请人： AUROBINDO PHARMA LTD

发明人： Sukumar Nandi ,  Akkina Naresh ,  Syam Prasad Reddy Rao Annareddy ,  Gona Bala Narsimha Reddy ,  Meenakshi Sunderam Sivakumaran

IPC分类号： C07D223/16

摘要： The present invention provides a process for the preparation of crystalline Lorcaserin hydrochloride hemihydrate of Formula (Ia), which comprises, Formula (Ia) (i) providing a solution of Lorcaserin base in a solvent; (ii) if water is present, removing water from the reaction mixture; (iii) adding hydrogen chloride to the reaction mixture; (iv) combining the reaction mixture with a suitable anti-solvent; and (v) isolating the crystalline Lorcaserin hydrochloride hemihydrate of Formula (Ia).

公开(公告)号：US10253005B2

公开(公告)日：2019-04-09

申请号：US15741859

申请日：2016-05-09

申请人： AUROBINDO PHARMA LTD ,  Sukumar Nandi ,  Shantan Kumar Reddy ,  Gona Bala Narashimha Reddy

发明人： Sukumar Nandi ,  Shantan Kumar Reddy ,  Gona Bala Narashimha Reddy ,  Sivakumaran Meenakshisundaram

IPC分类号： C07D277/40

摘要： The present invention provides a process for the preparation of α-Form crystals of Mirabegron using a solvent selected from water.