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公开(公告)号：US20130165343A1
公开(公告)日：2013-06-27
申请号：US13775928
申请日：2013-02-25
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6886 , C12Q2600/106 , C12Q2600/118 , C12Q2600/158
摘要： Methods for identifying multigene biomarkers for predicting sensitivity or resistance to an anti-cancer drug of interest, or multigene cancer prognostic biomarkers are disclosed. The disclosed methods are based on the classification of the mammalian genome into 51 transcription clusters, i.e., non-overlapping, functionally relevant groups of genes whose intra-group transcript levels are highly correlated. Also disclosed are specific multigene biomarkers for predicting sensitivity or resistance to tivozanib, or rapamycin, and a specific multigene biomarker for determining breast cancer prognosis, all of which were identified using the methods disclosed herein.
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公开(公告)号：US20130165337A1
公开(公告)日：2013-06-27
申请号：US13669275
申请日：2012-11-05
CPC分类号： C12Q1/6886 , C12Q2600/106 , C12Q2600/118 , C12Q2600/158
摘要： Methods for identifying multigene biomarkers for predicting sensitivity or resistance to an anti-cancer drug of interest, or multigene cancer prognostic biomarkers are disclosed. The disclosed methods are based on the classification of the mammalian genome into 51 transcription clusters, i.e., non-overlapping, functionally relevant groups of genes whose intra-group transcript levels are highly correlated. Also disclosed are specific multigene biomarkers for predicting sensitivity or resistance to tivozanib, or rapamycin, and a specific multigene biomarker for determining breast cancer prognosis, all of which were identified using the methods disclosed herein.
摘要翻译： 公开了用于鉴定用于预测感兴趣的抗癌药物或多基因癌症预后生物标志物的敏感性或抗性的多基因生物标志物的方法。 所公开的方法基于将哺乳动物基因组分类为51个转录簇，即组内转录水平高度相关的非重叠功能相关基因组。 还公开了用于预测对利托那尼或雷帕霉素的敏感性或抗性的特异性多基因生物标志物，以及用于确定乳腺癌预后的特异性多基因生物标志物，所有这些标记均使用本文公开的方法鉴定。
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