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公开(公告)号：US08829164B2
公开(公告)日：2014-09-09
申请号：US14070070
申请日：2013-11-01
发明人： Kerry Whalen , Steve Bottega , Andrea Boudrow , Lyne Breault , Ting Chen , James Gifford , May Han , Jinwei Jiang , Lorena Lerner , Qing Liu , Kristan Meetze , Sylvie Vincent , Solly Weiler , William M. Winston, Jr. , Jeno Gyuris
IPC分类号： C07K16/30
CPC分类号： C07K16/30 , A61K2039/505 , C07K16/2896 , C07K2317/24 , C07K2317/73 , C07K2317/76 , C07K2317/77 , C07K2317/92
摘要： Monoclonal antibodies that bind and inhibit activation of human RON (Recepteur d'Origine Nantais) are disclosed. The antibodies can be used to treat certain forms of cancer that are associated with activation of RON.
摘要翻译： 公开了结合并抑制人RON（Recepteur d'Origine Nantais）活化的单克隆抗体。 抗体可用于治疗与RON活化相关的特定形式的癌症。
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公开(公告)号：US09598498B2
公开(公告)日：2017-03-21
申请号：US14987374
申请日：2016-01-04
发明人： Sylvie Vincent , William M. Winston, Jr. , Fang Wang , Solly Weiler , Kristan Meetze , Lyne Breault , Steve Bottega , Ting Chen , Michael DePrima , Christina Fleet , Steven Tyler , Jin-Kyeung Woo , Jeno Gyuris
IPC分类号： A61K39/395 , C07K16/32 , C07K16/30 , A61K39/00
CPC分类号： C07K16/32 , A61K39/39558 , A61K2039/505 , C07K16/30 , C07K2317/24 , C07K2317/51 , C07K2317/515 , C07K2317/565 , C07K2317/73 , C07K2317/76 , C07K2317/92
摘要： Monoclonal antibodies that bind and inhibit activation of epidermal growth factor receptor related member ErbB3/HER3 are disclosed. The antibodies can be used to treat cell proliferative diseases and disorders, including certain forms of cancer, associated with activation of ErbB3/HER3.
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公开(公告)号：US11680108B2
公开(公告)日：2023-06-20
申请号：US16667056
申请日：2019-10-29
发明人： Sylvie Vincent , William M. Winston, Jr. , Fang Wang , Solly Weiler , Kristan Meetze , Lyne Breault , Steve Bottega , Ting Chen , Michael DePrima , Christina Fleet , Steven Tyler , Jin-Kyeung Woo , Jeno Gyuris
IPC分类号： A61K39/00 , C07K16/32 , C07K16/30 , A61K39/395
CPC分类号： C07K16/32 , C07K16/30 , A61K39/39558 , A61K2039/505 , C07K2317/24 , C07K2317/51 , C07K2317/515 , C07K2317/565 , C07K2317/73 , C07K2317/76 , C07K2317/92
摘要： Monoclonal antibodies that bind and inhibit activation of epidermal growth factor receptor related member ErbB3/HER3 are disclosed. The antibodies can be used to treat cell proliferative diseases and disorders, including certain forms of cancer, associated with activation of ErbB3/HER3.
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公开(公告)号：US20200299406A1
公开(公告)日：2020-09-24
申请号：US16667056
申请日：2019-10-29
发明人： Sylvie Vincent , William M. Winston, Jr. , Fang Wang , Solly Weiler , Kristan Meetze , Lyne Breault , Steve Bottega , Ting Chen , Michael DePrima , Christina Fleet , Steven Tyler , Jin-Kyeung Woo , Jeno Gyuris
摘要： Monoclonal antibodies that bind and inhibit activation of epidermal growth factor receptor related member ErbB3/HER3 are disclosed. The antibodies can be used to treat cell proliferative diseases and disorders, including certain forms of cancer, associated with activation of ErbB3/HER3.
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公开(公告)号：US20180195120A1
公开(公告)日：2018-07-12
申请号：US15823227
申请日：2017-11-27
发明人： Sylvie Vincent , Kristan Meetze , Bin Feng , Steven Tyler , Steve Bottega , Richard Nicoletti , Donna McIntosh , Jeno Gyuris
IPC分类号： C12Q1/6881 , G01N33/574 , A61K39/395
CPC分类号： C12Q1/6881 , A61K39/39558 , G01N33/574
摘要： A diagnostic method for predicting quantitatively whether a human tumor will be sensitive or resistant to treatment with an ERBB3 inhibitor, e.g, an anti-ERBB3 antibody, is disclosed. The method is based on measurement of NRG1 expression at the RNA level, or at the protein level, in a tissue sample from the tumor.
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公开(公告)号：US09828635B2
公开(公告)日：2017-11-28
申请号：US14349916
申请日：2012-10-05
发明人： Sylvie Vincent , Kristan Meetze , Bin Feng , Steven Tyler , Steve Bottega , Richard Nicoletti , Donna McIntosh , Jeno Gyuris
IPC分类号： A61K39/395 , C12Q1/68 , G01N33/574
CPC分类号： C12Q1/6881 , A61K39/39558 , G01N33/574
摘要： A diagnostic method for predicting quantitatively whether a human tumor will be sensitive or resistant to treatment with an ERBB3 inhibitor, e.g, an anti-ERBB3 antibody, is disclosed. The method is based on measurement of NRG1 expression at the RNA level, or at the protein level, in a tissue sample from the tumor.
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公开(公告)号：US20140242597A1
公开(公告)日：2014-08-28
申请号：US14349916
申请日：2012-10-05
发明人： Sylvie Vincent , Kristan Meetze , Bin Feng , Steven Tyler , Steve Bottega , Richard Nicoletti , Donna McIntosh , Jeno Gyuris
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6881 , A61K39/39558 , G01N33/574
摘要： A diagnostic method for predicting quantitatively whether a human tumor will be sensitive or resistant to treatment with an ERBB3 inhibitor, e.g, an anti-ERBB3 antibody, is disclosed. The method is based on measurement of NRG1 expression at the RNA level, or at the protein level, in a tissue sample from the tumor.
摘要翻译： 公开了一种诊断方法，用于定量地预测人肿瘤是否对ERBB3抑制剂例如抗ERBB3抗体的治疗敏感或抗性。 该方法基于来自肿瘤的组织样品中RNA水平或蛋白质水平的NRG1表达的测量。
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公开(公告)号：US20180030149A1
公开(公告)日：2018-02-01
申请号：US15448164
申请日：2017-03-02
发明人： Sylvie Vincent , William M. Winston, Jr. , Fang Wang , Solly Weiler , Kristan Meetze , Lyne Breault , Steve Bottega , Ting Chen , Michael DePrima , Christina Fleet , Steven Tyler , Jin-Kyeung Woo , Jeno Gyuris
IPC分类号： C07K16/32 , C07K16/30 , A61K39/395 , A61K39/00
CPC分类号： C07K16/32 , A61K39/39558 , A61K2039/505 , C07K16/30 , C07K2317/24 , C07K2317/51 , C07K2317/515 , C07K2317/565 , C07K2317/73 , C07K2317/76 , C07K2317/92
摘要： Monoclonal antibodies that bind and inhibit activation of epidermal growth factor receptor related member ErbB3/HER3 are disclosed. The antibodies can be used to treat cell proliferative diseases and disorders, including certain forms of cancer, associated with activation of ErbB3/HER3.
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公开(公告)号：US20160264679A1
公开(公告)日：2016-09-15
申请号：US14987374
申请日：2016-01-04
发明人： Sylvie Vincent , William M. Winston, JR. , Fang Wang , Solly Weiler , Kristan Meetze , Lyne Breault , Steve Bottega , Ting Chen , Michael DePrima , Christina Fleet , Steven Tyler , Jin-Kyeung Woo , Jeno Gyuris
IPC分类号： C07K16/32
CPC分类号： C07K16/32 , A61K39/39558 , A61K2039/505 , C07K16/30 , C07K2317/24 , C07K2317/51 , C07K2317/515 , C07K2317/565 , C07K2317/73 , C07K2317/76 , C07K2317/92
摘要： Monoclonal antibodies that bind and inhibit activation of epidermal growth factor receptor related member ErbB3/HER3 are disclosed. The antibodies can be used to treat cell proliferative diseases and disorders, including certain forms of cancer, associated with activation of ErbB3/HER3.
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公开(公告)号：US09228021B2
公开(公告)日：2016-01-05
申请号：US13919582
申请日：2013-06-17
发明人： Sylvie Vincent , William M. Winston, Jr. , Fang Wang , Solly Weiler , Kristan Meetze , Lyne Breault , Steve Bottega , Ting Chen , Michael DePrima , Christina Fleet , Steven Tyler , Jin-Kyeung Woo , Jeno Gyuris
CPC分类号： C07K16/32 , A61K39/39558 , A61K2039/505 , C07K16/30 , C07K2317/24 , C07K2317/51 , C07K2317/515 , C07K2317/565 , C07K2317/73 , C07K2317/76 , C07K2317/92
摘要： Monoclonal antibodies that bind and inhibit activation of epidermal growth factor receptor related member ErbB3/HER3 are disclosed. The antibodies can be used to treat cell proliferative diseases and disorders, including certain forms of cancer, associated with activation of ErbB3/HER3.
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