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    COCRYSTALS OF UPADACITINIB
    3.
    发明公开
    COCRYSTALS OF UPADACITINIB 审中-公开

    公开(公告)号：US20240043434A1

    公开(公告)日：2024-02-08

    申请号：US18482794

    申请日：2023-10-06

    Applicant: AbbVie Inc.

    Inventor： Alessandra Mattei

    IPC: C07D487/14

    CPC classification number: C07D487/14 ,  C07B2200/13

    Abstract: The disclosure relates to cocrystals of solid state forms of (3S,4R)-3-ethyl-4-(3H-imidazo[1,2-a]pyrrolo[2,3-e]-pyrazin-8-yl)-N-(2,2,2-trifluoroethyl)pyrrolidine-1-carboxamide (Compound 1). Specifically, the present disclosure relates to cocrystals of Compound 1 and a suitable coformer, such as a substituted benzoic acid.

    2,2-DIFLUOROPROPIONAMIDE DERIVATIVES OF BARDOXOLONE METHYL, POLYMORPHIC FORMS AND METHODS OF USE THEREOF
    5.
    发明申请
    2,2-DIFLUOROPROPIONAMIDE DERIVATIVES OF BARDOXOLONE METHYL, POLYMORPHIC FORMS AND METHODS OF USE THEREOF 有权
    苯乙烯酮甲基的多异戊二酰胺衍生物，多晶型及其使用方法

    公开(公告)号：US20140323579A1

    公开(公告)日：2014-10-30

    申请号：US14260532

    申请日：2014-04-24

    Applicant: AbbVie Inc.

    Inventor： Ahmad Y. Sheikh ,  Alessandra Mattei ,  Xiu C. Wang

    IPC: C07J63/00

    CPC classification number: C07J63/008 ,  C07B2200/13

    Abstract: The present invention relates generally to the compound: N-((4aS,6aR,6bS,8aR,12aS,14aR,14bS)-11-cyano-2,2,6a,6b,9,9,12a-heptamethyl-10,14-dioxo-1,2,3,4,4a,5,6,6a,6b,7,8,8a,9,10,12a,14,14a,14b-octadecahydropicen-4a-yl)-2,2-difluoropropanamide, polymorphic forms thereof, methods for preparation and use thereof, pharmaceutical compositions thereof, and kits and articles of manufacture thereof.

    Abstract translation: 本发明一般涉及化合物：N - （（4aS，6aR，6bS，8aR，12aS，14aR，14bS）-11-氰基-2,2,6a，6b，9,9,12a-七甲基-10， 14-二氧代-1,2,3,4,4a，5,6,6a，6b，7,8,8a，9,10,12a，14,14a，14b-十八氢en啶-4a-基）-2,2 - 二氟丙酰胺，其多晶型物，其制备方法和用途，其药物组合物，以及试剂盒及其制备方法。

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