公开(公告)号：US20210023012A1

公开(公告)日：2021-01-28

申请号：US16837576

申请日：2020-04-01

Applicant: AbbVie Inc.

Inventor： Wei Liu ,  Hoi Kei Lon ,  Sven Mensing ,  Jeffrey Schmidt ,  Neha Thakre ,  Thin Yu Tu

IPC: A61K9/24 ,  A61P31/14 ,  A61K38/06 ,  A61K31/454 ,  A61K9/28 ,  A61K9/20 ,  A61K9/50 ,  A61K9/48

Abstract: The present invention features solid pharmaceutical compositions comprising Compound 1 and Compound 2. In one embodiment, the solid pharmaceutical composition includes (1) a first type of film-coated granules which comprise 50 mg of Compound 1, as well as a pharmaceutically acceptable hydrophilic polymer and a pharmaceutically acceptable surfactant, all of which are formulated in amorphous solid dispersion; and (2) a second type of film-coated granules which comprise 20 mg of Compound 2, as well as a pharmaceutically acceptable hydrophilic polymer and a pharmaceutically acceptable surfactant, all of which are formulated in amorphous solid dispersion.