公开(公告)号：US20250114531A1

公开(公告)日：2025-04-10

申请号：US18661199

申请日：2024-05-10

Applicant: AbbVie Inc.

Inventor： Martin J. Gibler ,  Mark A. Bennett ,  Kenneth R. Waeber ,  Kenneth E. Hogue ,  Christoph L. Gillum ,  Patrick A. Harrell ,  David A. Parrott ,  Sean E. Mackey ,  Rajkumar V. Conjeevaram ,  Thomas Rebne ,  Bradley A. Clark ,  Jeremy L. Hemingway ,  Ji Zhou

IPC: A61M5/315 ,  A61M5/145 ,  A61M5/31 ,  B65B1/04

Abstract: A syringe containing a high water content product and for use in a drug infusion system is provided. The syringe includes a plunger carrying front and rear o-rings made of a diene rubber compound such as chlorobutyl rubber or bromobutyl rubber to impart very low gas permeability characteristics to the o-rings. The plunger may be molded as a single part or in two parts. If molded as one part with radially-engaging mold portions, the seal glands in the plunger may include parting lines from the mold. If molded as two parts with axially-engaging mold portions, the front seal gland may include a sealing surface and under cut that has no parting line. The o-rings may be surface treated with a lubricant to improve sealing where the molding process gives rise to parting lines in the seal glands, which can result in leak paths on the ID of the o-rings. The o-rings provide a gas-tight sliding seal that can withstand temperature changes from −25° C. to 40° C. and the resulting thermal expansion and contraction of the high water content product.