公开(公告)号：US09751850B2

公开(公告)日：2017-09-05

申请号：US14532573

申请日：2014-11-04

Applicant: AbbVie Inc.

Inventor： Richard J. Perner ,  Michael E. Kort ,  Stanley DiDomenico ,  Jun Chen ,  Anil Vasudevan

IPC: A61K31/44 ,  A61K45/06 ,  A61K31/381 ,  C07D333/22 ,  C07D213/53 ,  C07D215/12 ,  C07D217/14 ,  C07D333/20 ,  A61K31/47 ,  A61K31/472 ,  C07D213/61 ,  C07D213/64

CPC classification number: C07D333/22 ,  A61K31/381 ,  A61K31/44 ,  A61K31/47 ,  A61K31/472 ,  A61K45/06 ,  C07D213/53 ,  C07D213/61 ,  C07D213/64 ,  C07D215/12 ,  C07D217/14 ,  C07D333/20

Abstract: Compounds of formula (I) wherein R1, R2, R3, and Y are defined in the description are TRPA1 antagonists. Compositions comprising such compounds and methods for treating conditions and disorders using such compounds and compositions are also disclosed.

公开(公告)号：US20150065538A1

公开(公告)日：2015-03-05

申请号：US14532573

申请日：2014-11-04

Applicant: AbbVie Inc.

Inventor： Richard J. Perner ,  Michael E. Kort ,  Stanley DiDomenico ,  Jun Chen ,  Anil Vasudevan

IPC: C07D333/22 ,  A61K31/44 ,  A61K45/06 ,  A61K31/381 ,  A61K31/472 ,  C07D213/53 ,  C07D215/12 ,  A61K31/47 ,  C07D217/14 ,  C07D213/61 ,  C07D213/64

CPC classification number: C07D333/22 ,  A61K31/381 ,  A61K31/44 ,  A61K31/47 ,  A61K31/472 ,  A61K45/06 ,  C07D213/53 ,  C07D213/61 ,  C07D213/64 ,  C07D215/12 ,  C07D217/14 ,  C07D333/20

Abstract: Compounds of formula (I) wherein R1, R2, R3, and Y are defined in the description are TRPA1 antagonists.Compositions comprising such compounds and methods for treating conditions and disorders using such compounds and compositions are also disclosed.