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1.发明授权Aryl and arylalkyl substituted pyrazolyl and pyrimidinyl tricyclic enones as antioxidant inflammation modulators 有权芳基和芳基烷基取代的吡唑基和嘧啶基三环烯酮作为抗氧化剂炎症调节剂公开(公告)号：US09464082B2
公开(公告)日：2016-10-11
申请号：US14604129
申请日：2015-01-23
发明人： Pamela Donner , Rolf Wagner , Jason Shanley , Howard Heyman , Allan Krueger , Hui-Ju Chen , Michael Rozema , David Grampovnik , Melean Visnick , Eric Anderson , Xin Jiang , Christopher F. Bender , Gary Louis Bolton , Bradley William Caprathe , Chitase Lee , William Howard Roark
IPC分类号： C07D231/54 , C07D239/70 , C07D239/72 , C07D401/04 , C07D403/04 , C07D417/04 , C07D471/04 , C07D413/04
CPC分类号： C07D471/04 , C07D231/54 , C07D239/70 , C07D239/72 , C07D401/04 , C07D403/04 , C07D413/04 , C07D417/04
摘要： The present application relates to: (a) compounds of Formula (I): and salts thereof, wherein R1, R2, R3, R4, R5, R6, m, n, X and Y are as defined in the specification; (b) compositions comprising such compounds and salts; and (c) methods of use of such compounds, salts, and compositions, particularly use for the treatment and prevention of diseases such as those associated with oxidative stress and inflammation.
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2.发明申请ARYL AND ARYLALKYL SUBSTITUTED PYRAZOLYL AND PYRIMIDINYL TRICYCLIC ENONES AS ANTIOXIDANT INFLAMMATION MODULATORS 有权ARYL和ARYLALKYL取代的吡唑并吡啶并吡啶酮作为抗氧化剂的炎症调节剂公开(公告)号：US20150225397A1
公开(公告)日：2015-08-13
申请号：US14604129
申请日：2015-01-23
发明人： Pamela Donner , Rolf Wagner , Jason Shanley , Howard Heyman , Allan Krueger , Hui-Ju Chen , Michael Rozema , David Grampovnik , Melean Visnick , Eric Anderson , Xin Jiang , Christopher F. Bender , Gary Louis Bolton , Bradley William Caprathe , Chitase Lee , William Howard Roark
IPC分类号： C07D471/04 , C07D231/54 , C07D413/04 , C07D403/04 , C07D417/04 , C07D239/70 , C07D401/04
CPC分类号： C07D471/04 , C07D231/54 , C07D239/70 , C07D239/72 , C07D401/04 , C07D403/04 , C07D413/04 , C07D417/04
摘要： The present application relates to: (a) compounds of Formula (I): and salts thereof, wherein R1, R2, R3, R4, R5, R6, m, n, X and Y are as defined in the specification; (b) compositions comprising such compounds and salts; and (c) methods of use of such compounds, salts, and compositions, particularly use for the treatment and prevention of diseases such as those associated with oxidative stress and inflammation.
摘要翻译： 本申请涉及：（a）式（I）化合物及其盐，其中R 1，R 2，R 3，R 4，R 5，R 6，m，n，X和Y如说明书中所定义; （b）包含这些化合物和盐的组合物; 和（c）使用这些化合物，盐和组合物的方法，特别用于治疗和预防与氧化应激和炎症有关的疾病。
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