公开(公告)号：US20030073703A1

公开(公告)日：2003-04-17

申请号：US10201524

申请日：2002-07-23

Applicant: Abbott Laboratories and Ligand Pharmaceuticals Incorporated

Inventor： Michael J. Coghlan ,  James P. Edwards ,  Steven W. Elmore ,  Todd K. Jones ,  Michael E. Kort ,  Philip R. Kym ,  Jimmie L. Moore ,  John K. Pratt ,  Alan X. Wang

IPC: A61K031/519 ,  A61K031/4741 ,  C07D491/02 ,  C07D471/02

CPC classification number: C07D491/04

Abstract: Compounds having Formula I 1 are useful for partially or fully antagonizing, repressing, agonizing, or modulating the glucocorticoid receptor and treating immune, autoimmune and inflammatory diseases in a mammal. Also disclosed are pharmaceutical compositions comprising compounds of Formula I and methods of inhibiting immune or autoimmune diseases in a mammal.

Abstract translation: 具有式I的化合物可用于部分或完全拮抗，镇压，激动或调节糖皮质激素受体并治疗哺乳动物的免疫，自身免疫和炎性疾病。 还公开了包含式I化合物的药物组合物和在哺乳动物中抑制免疫或自身免疫性疾病的方法。