公开(公告)号：US20240307331A1

公开(公告)日：2024-09-19

申请号：US18173743

申请日：2021-08-23

申请人： Abrexa Pharmaceuticals, Inc. ,  The Penn State Research Foundation

发明人： Jesus E. VILLAFRANCA ,  Charles Richard KISSINGER ,  Guohong LI

IPC分类号： A61K31/167 ,  A61K38/48 ,  A61P7/04 ,  A61P9/10

CPC分类号： A61K31/167 ,  A61K38/482 ,  A61P7/04 ,  A61P9/10 ,  C12Y304/21068

摘要： Hemorrhage and vascular instability can be induced by thrombolytic and anti-coagulant therapies. Presented herein, in certain aspects, are methods for the treatment and/or prevention of hemorrhage and vascular instability that comprise administering a compound disclosed herein to a subject in need thereof.

公开(公告)号：US20220273590A1

公开(公告)日：2022-09-01

申请号：US17435683

申请日：2020-03-02

申请人： ABREXA PHARMACEUTICALS, INC.

发明人： Jesus E. VILLAFRANCA ,  Charles Richard KISSINGER

IPC分类号： A61K31/15

摘要： Presented herein, in certain aspects, are methods of preventing, reducing, delaying and treating post-operative cognitive dysfunction, or one or more symptoms thereof, by administering a compound disclosed herein to a subject prior to, during and/or after a medical procedure.

公开(公告)号：US20240277640A1

公开(公告)日：2024-08-22

申请号：US18615533

申请日：2024-03-25

申请人： Abrexa Pharmaceuticals, Inc.

发明人： Jesus E. VILLAFRANCA ,  Charles Richard KISSINGER

IPC分类号： A61K31/167 ,  A61K31/4365 ,  A61K31/616 ,  A61K31/7064 ,  A61K31/727 ,  A61K38/48 ,  A61P7/02

CPC分类号： A61K31/167 ,  A61K31/4365 ,  A61K31/616 ,  A61K31/7064 ,  A61K31/727 ,  A61K38/482 ,  A61P7/02

摘要： Presented herein are compositions and methods for preventing, reducing, delaying and treating a coronavirus infection and related disorders such as respiratory distress, disseminated intravascular coagulation, and central nervous system pathologies caused by coronavirus infection.