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公开(公告)号：US11951156B2
公开(公告)日：2024-04-09
申请号：US16851287
申请日：2020-04-17
Inventor： Paul B. Yu , Asya Grinberg , Dianne S. Sako , Roselyne Castonguay , Rita Steeves , Ravindra Kumar
CPC classification number: A61K38/179 , A61K47/6811 , A61P9/12 , C07K14/71 , C07K19/00 , C07K2319/30 , C07K2319/32
Abstract: In some aspects, the invention teaches pharmaceutical compositions that include a TGF-β ligand trap, and methods of using a TGF-β ligand trap to treat, prevent, or reduce the progression rate of pulmonary hypertension (PH). The invention also provides methods of using a TGF-β ligand trap to treat, prevent, or reduce the progression rate of a variety of conditions including, but not limited to, pulmonary vascular remodeling, pulmonary fibrosis, right ventricular hypertrophy, diseases associated with excessive TGF-β signaling, diseases associated with excessive GDF15 signaling, and diseases associated with excessive PAI-1 signaling. The invention further provides methods of using a TGF-β ligand trap to reduce right ventricular systolic pressure in a subject.
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公开(公告)号：US20210230252A1
公开(公告)日：2021-07-29
申请号：US17229132
申请日：2021-04-13
Applicant: Acceleron Pharma Inc.
Inventor： Ravindra Kumar , Asya Grinberg , Dianne S. Sako , Roselyne Castonguay , Rita Steeves
IPC: C07K14/71 , C07K14/495 , C07K16/22
Abstract: In certain aspects, the present disclosure relates to polypeptides comprising a truncated, ligand-binding portion of the extracellular domain of TβRII polypeptide useful to selectively antagonize a TβRII ligand. The disclosure further provides compositions and methods for use in treating or preventing TGFβ associated disorders.
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3.发明授权公开(公告)号：US10682392B2
公开(公告)日：2020-06-16
申请号：US15037852
申请日：2014-11-21
Inventor： Paul Yu , Asya Grinberg , Dianne S. Sako , Roselyne Castonguay , Rita Steeves , Ravindra Kumar
IPC: A61P9/12 , A61K38/17 , C07K14/71 , C07K14/705 , C07K19/00
Abstract: In some aspects, the invention teaches pharmaceutical compositions that include a TGF-beta ligand trap, and methods of using a TGF-beta ligand trap to treat, prevent, or reduce the progression rate of pulmonary hypertension (PH). The invention also provides methods of using a TGF-beta ligand trap to treat, prevent, or reduce the progression rate of a variety of conditions including, but not limited to, pulmonary vascular remodeling, pulmonary fibrosis, right ventricular hypertrophy, diseases associated with excessive TGF-beta signaling, diseases associated with excessive GDF15 signaling, and diseases associated with excessive PAI-1 signaling. The invention further provides methods of using a TGF-beta ligand trap to reduce right ventricular systolic pressure in a subject.
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公开(公告)号：US20180179261A1
公开(公告)日：2018-06-28
申请号：US15714015
申请日：2017-09-25
Applicant: Acceleron Pharma Inc.
Inventor： Ravindra Kumar , Asya Grinberg , Dianne S. Sako , Roselyne Castonguay , Rita Steeves
IPC: C07K14/71 , C07K14/495 , C07K16/22 , A61K38/00
CPC classification number: C07K14/71 , A61K38/00 , C07K14/495 , C07K16/22 , C07K2317/76 , C07K2319/30 , C07K2319/31
Abstract: In certain aspects, the present disclosure relates to polypeptides comprising a truncated, ligand-binding portion of the extracellular domain of TβRII polypeptide useful to selectively antagonize a TβRII ligand. The disclosure further provides compositions and methods for use in treating or preventing TGFβ associated disorders.
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公开(公告)号：US20150056199A1
公开(公告)日：2015-02-26
申请号：US14465182
申请日：2014-08-21
Applicant: Acceleron Pharma, Inc.
Inventor： Ravindra Kumar , Asya Grinberg , Dianne S. Sako , Roselyne Castonguay , Rita Steeves
IPC: C07K14/71
CPC classification number: C07K14/71 , A61K38/00 , C07K14/495 , C07K16/22 , C07K2317/76 , C07K2319/30 , C07K2319/31
Abstract: In certain aspects, the present disclosure relates to polypeptides comprising a truncated, ligand-binding portion of the extracellular domain of TβRII polypeptide useful to selectively antagonize a TβRII ligand. The disclosure further provides compositions and methods for use in treating or preventing TGFβ associated disorders.
Abstract translation: 在某些方面，本公开内容涉及包含用于选择性拮抗T＆Bgr RII配体的T细胞外结构域的截短的配体结合部分的多肽。 本公开进一步提供用于治疗或预防TGFβ的组合物和方法; 相关疾病。
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Patent Agency Ranking
公开(公告)号：US10745462B2
公开(公告)日：2020-08-18
申请号：US16393277
申请日：2019-04-24
Applicant: Acceleron Pharma Inc.
Inventor： Ravindra Kumar , Asya Grinberg , Dianne S. Sako , Roselyne Castonguay , Rita Steeves
IPC: A61K38/00 , C07K14/71 , C07K14/495 , C07K16/22
Abstract: In certain aspects, the present disclosure relates to polypeptides comprising a truncated, ligand-binding portion of the extracellular domain of TβRII polypeptide useful to selectively antagonize a TβRII ligand. The disclosure further provides compositions and methods for use in treating or preventing TGFβ associated disorders.
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公开(公告)号：US20190284257A1
公开(公告)日：2019-09-19
申请号：US16393277
申请日：2019-04-24
Applicant: Acceleron Pharma Inc.
Inventor： Ravindra Kumar , Asya Grinberg , Dianne S. Sako , Roselyne Castonguay , Rita Steeves
IPC: C07K14/71 , C07K16/22 , C07K14/495
Abstract: In certain aspects, the present disclosure relates to polypeptides comprising a truncated, ligand-binding portion of the extracellular domain of TβRII polypeptide useful to selectively antagonize a TβRII ligand. The disclosure further provides compositions and methods for use in treating or preventing TGFβ associated disorders.
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公开(公告)号：US10316076B2
公开(公告)日：2019-06-11
申请号：US15714015
申请日：2017-09-25
Applicant: Acceleron Pharma Inc.
Inventor： Ravindra Kumar , Asya Grinberg , Dianne S. Sako , Roselyne Castonguay , Rita Steeves
IPC: C07K14/71 , C07K14/495 , C07K16/22 , A61K38/00
Abstract: In certain aspects, the present disclosure relates to polypeptides comprising a truncated, ligand-binding portion of the extracellular domain of TβRII polypeptide useful to selectively antagonize a TβRII ligand. The disclosure further provides compositions and methods for use in treating or preventing TGFβ associated disorders.
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公开(公告)号：US09809637B2
公开(公告)日：2017-11-07
申请号：US15044883
申请日：2016-02-16
Applicant: Acceleron Pharma Inc.
Inventor： Ravindra Kumar , Asya Grinberg , Dianne S. Sako , Roselyne Castonguay , Rita Steeves
IPC: C07K14/71 , C07K14/495 , C07K16/22 , A61K38/00
CPC classification number: C07K14/71 , A61K38/00 , C07K14/495 , C07K16/22 , C07K2317/76 , C07K2319/30 , C07K2319/31
Abstract: In certain aspects, the present disclosure relates to polypeptides comprising a truncated, ligand-binding portion of the extracellular domain of TβRII polypeptide useful to selectively antagonize a TβRII ligand. The disclosure further provides compositions and methods for use in treating or preventing TGFβ associated disorders.
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公开(公告)号：US11008377B2
公开(公告)日：2021-05-18
申请号：US16777546
申请日：2020-01-30
Applicant: Acceleron Pharma Inc.
Inventor： Ravindra Kumar , Asya Grinberg , Dianne S. Sako , Roselyne Castonguay , Rita Steeves
IPC: A61K38/00 , C07K14/71 , C07K14/495 , C07K16/22
Abstract: In certain aspects, the present disclosure relates to polypeptides comprising a truncated, ligand-binding portion of the extracellular domain of TβRII polypeptide useful to selectively antagonize a TβRII ligand. The disclosure further provides compositions and methods for use in treating or preventing TGFβ associated disorders.
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