公开(公告)号：US10660988B2

公开(公告)日：2020-05-26

申请号：US15738644

申请日：2016-12-13

申请人： Acro Biomedical Company. Ltd.

发明人： Shing-Jye Chen ,  Fan-Wei Tseng ,  Kai-Chi Ku ,  Dar-Jen Hsieh

IPC分类号： A61L27/36 ,  A61L27/38 ,  C12N5/079

摘要： A method of producing an acellular cornea includes steps of subjecting a cornea of an animal to a decellularization process, and has not the step of treating the cornea with a protease, a chelating agent, a detergent, a glycerol, or a combination thereof. When a native cornea is processed by the method, the native structure and conformation of the native cornea are preserved while immunogenic matters are reduced to a level that the thus produced cornea may serve as a three-dimensional scaffold for host cells to grow thereon after transplantation.

公开(公告)号：US10881761B2

公开(公告)日：2021-01-05

申请号：US15739163

申请日：2016-08-11

申请人： Acro Biomedical Company. Ltd.

发明人： Jun-Jie Wang ,  Pei-Hua Tsai ,  Kai-Chi Ku ,  Dar-Jen Hsieh

IPC分类号： C07K1/36 ,  A61L27/24 ,  A61K8/65 ,  A61L27/36 ,  C07K14/78 ,  A61L27/20 ,  A61L27/52 ,  A61K38/00

摘要： Disclosed herein is a method of producing collagen particles. Each of the collagen particle is characterized in having a particle size of about 10-250 μm, in which the integrity of collagen fibers therein is relatively intact.