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1.发明申请1-PHENYL-SUBSTITUTED HETEROCYCLYL DERIVATIVES AND THEIR USE AS PROSTAGLANDIN D2 RECEPTOR MODULATORS 有权1-苯基取代的杂环衍生物及其作为PROSTAGLANDIN D2受体调节剂的用途公开(公告)号：US20150158883A1
公开(公告)日：2015-06-11
申请号：US14412877
申请日：2013-07-04
IPC分类号： C07D513/04
CPC分类号： C07D513/04
摘要： The present invention relates to 1-phenyl-substituted heterocyclyl derivatives of the formula (I), wherein Y, Z, R1, R2, R3 and R4 are as described in the description and their use as prostaglandin receptor modulators, most particularly as prostaglandin D2 receptor modulators, in the treatment of various prostaglandin-mediated diseases and disorders, to pharmaceutical compositions containing these compounds and to processes for their preparation.
摘要翻译： 本发明涉及式（I）的1-苯基取代的杂环基衍生物，其中Y，Z，R 1，R 2，R 3和R 4如说明书中所述及其作为前列腺素受体调节剂的用途，最特别地涉及前列腺素D2 受体调节剂，用于治疗各种前列腺素介导的疾病和病症，含有这些化合物的药物组合物及其制备方法。
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公开(公告)号：US11136317B2
公开(公告)日：2021-10-05
申请号：US16777308
申请日：2020-01-30
IPC分类号： C07D413/12 , C07D413/14 , C07D417/12 , C07D263/54 , C07D263/58 , C07D277/62 , C07D417/14 , C07D471/10 , C07D491/107 , A61P11/00 , A61P35/04
摘要： The invention relates to 2,5-disubstituted benzoxazole and benzothiazole derivatives of Formula (I) wherein L, X, Y, and ring (A) are as described in the description, their preparation and their use as pharmaceutically active compounds. Said compounds may be useful for the prevention or treatment of diseases or disorders associated with impaired reactive oxygen species (ROS) production, and/or for the prevention or treatment of various fibrotic diseases.
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公开(公告)号：US09255090B2
公开(公告)日：2016-02-09
申请号：US14367823
申请日：2012-12-20
IPC分类号： C07D209/44 , C07D217/06 , C07D223/06 , C07D223/16 , C07D401/06 , C07D405/06 , C07D413/06 , C07D417/06 , A61K31/47 , C07D401/12
摘要： The present invention relates to phenyl-substituted heterocyclyl derivatives of the formula (I), wherein Z, n, m, R1, R2, R3, R4, R5, R6, R7 and R8 are as described in the description and their use as prostaglandin receptor modulators, most particularly as prostaglandin D2 receptor modulators, in the treatment of various prostaglandin-mediated diseases and disorders, to pharmaceutical compositions containing these compounds and to processes for their preparation.
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公开(公告)号：US20200165235A1
公开(公告)日：2020-05-28
申请号：US16777308
申请日：2020-01-30
IPC分类号： C07D413/12 , C07D491/107 , C07D471/10 , C07D417/14 , C07D417/12 , C07D413/14 , A61P35/04 , A61P11/00 , C07D277/62 , C07D263/58 , C07D263/54
摘要： The invention relates to 2,5-disubstituted benzoxazole and benzothiazole derivatives of Formula (I) wherein L, X, Y, and ring (A) are as described in the description, their preparation and their use as pharmaceutically active compounds. Said compounds may be useful for the prevention or treatment of diseases or disorders associated with impaired reactive oxygen species (ROS) production, and/or for the prevention or treatment of various fibrotic diseases.
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公开(公告)号：US10584118B2
公开(公告)日：2020-03-10
申请号：US15739083
申请日：2016-06-21
IPC分类号： C07D413/12 , C07D413/14 , C07D417/12 , C07D263/54 , C07D263/58 , C07D277/62 , C07D417/14 , C07D471/10 , C07D491/107 , A61P11/00 , A61P35/04
摘要： The invention relates to 2,5-disubstituted benzoxazole and benzothiazole derivatives of Formula (I) wherein L, X, Y, and ring (A) are as described in the description, their preparation and their use as pharmaceutically active compounds. Said compounds may be useful for the prevention or treatment of diseases or disorders associated with impaired reactive oxygen species (ROS) production, and/or for the prevention or treatment of various fibrotic diseases.
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6.发明授权1-phenyl-substituted heterocyclyl derivatives and their use as prostaglandin D2 receptor modulators 有权1-苯基取代的杂环基衍生物及其作为前列腺素D2受体调节剂的用途公开(公告)号：US09169270B2
公开(公告)日：2015-10-27
申请号：US14412877
申请日：2013-07-04
IPC分类号： C07D513/02 , C07D513/04
CPC分类号： C07D513/04
摘要： The present invention relates to 1-phenyl-substituted heterocyclyl derivatives of the formula (I), wherein Y, Z, R1, R2, R3 and R4 are as described in the description and their use as prostaglandin receptor modulators, most particularly as prostaglandin D2 receptor modulators, in the treatment of various prostaglandin-mediated diseases and disorders, to pharmaceutical compositions containing these compounds and to processes for their preparation.
摘要翻译： 本发明涉及式（I）的1-苯基取代的杂环基衍生物，其中Y，Z，R 1，R 2，R 3和R 4如说明书中所述及其作为前列腺素受体调节剂的用途，最特别地涉及前列腺素D2 受体调节剂，用于治疗各种前列腺素介导的疾病和病症，含有这些化合物的药物组合物及其制备方法。
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7.发明申请Heterocyclyl Derivatives and their use as Prostaglandin D2 Receptor Modulators 审中-公开杂环衍生物及其作为前列腺素D2受体调节剂的用途公开(公告)号：US20150252036A1
公开(公告)日：2015-09-10
申请号：US14367823
申请日：2012-12-20
IPC分类号： C07D417/06 , C07D223/16 , C07D405/06 , C07D401/06 , C07D401/12 , C07D413/06 , C07D217/06 , C07D209/44
CPC分类号： C07D417/06 , C07D209/44 , C07D217/06 , C07D223/06 , C07D223/16 , C07D401/06 , C07D401/12 , C07D405/06 , C07D413/06
摘要： The present invention relates to phenyl-substituted heterocyclyl derivatives of the formula (I), wherein Z, n, m, R1, R2, R3, R4, R5, R6, R7 and R8 are as described in the description and their use as prostaglandin receptor modulators, most particularly as prostaglandin D2 receptor modulators, in the treatment of various prostaglandin-mediated diseases and disorders, to pharmaceutical compositions containing these compounds and to processes for their preparation.
摘要翻译： 本发明涉及式（I）的苯基取代的杂环基衍生物，其中Z，n，m，R1，R2，R3，R4，R5，R6，R7和R8如说明书中所述及其作为前列腺素的用途 受体调节剂，最特别地作为前列腺素D2受体调节剂，用于治疗各种前列腺素介导的疾病和病症，含有这些化合物的药物组合物及其制备方法。
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