公开(公告)号：US20130330837A1

公开(公告)日：2013-12-12

申请号：US13943031

申请日：2013-07-16

申请人： Acumen Pharmaceuticals, Inc. ,  Northwestern University

发明人： Mary P. Lambert ,  Pauline T. Velasco ,  Lei Chang ,  Kirsten L. Viola ,  Sara J. Fernandez ,  Pascale N. Lacor ,  Daliya Khuon ,  Yuesong Gong ,  William L. Klein ,  Grant A. Krafft

IPC分类号： C07K16/18

CPC分类号： C07K16/18 ,  C07K2317/76 ,  G01N33/6896 ,  G01N2333/4709 ,  G01N2800/2821

摘要： Disclosed herein are antibodies that bind with high specificity to soluble oligomers of amyloid β (Abeta) and methods utilizing such antibodies. The antibodies are able to distinguish between Alzheimer's Disease (AD) and control human brain extracts. The antibodies identify endogenous Abeta oligomers in AD brain slices and also bind to Abeta oligomers on cultured hippocampal cells. The antibodies neutralize endogenous Abeta oligomers and Abeta oligomers produced in solution.

摘要翻译： 本文公开了对淀粉样蛋白β（Abeta）的可溶性低聚物和使用这种抗体的方法具有高特异性结合的抗体。 抗体能够区分阿尔茨海默病（AD）和对照人脑提取物。 抗体鉴定AD脑切片中的内源性Aβ寡聚物，并且还结合培养的海马细胞上的Abeta寡聚物。 抗体中和溶液中产生的内源性Aβ低聚物和Abeta寡聚体。