公开(公告)号：USD655379S1

公开(公告)日：2012-03-06

申请号：US29391254

申请日：2011-05-05

申请人： Adam Doyle ,  John Mansell ,  Ross Leslie Palmer ,  Istvan Galambos ,  Aaron Kelly

设计人： Adam Doyle ,  John Mansell ,  Ross Leslie Palmer ,  Istvan Galambos ,  Aaron Kelly

公开(公告)号：US20230285440A1

公开(公告)日：2023-09-14

申请号：US18302841

申请日：2023-04-19

申请人： John Mansell

发明人： John Mansell

IPC分类号： A61K31/713 ,  A61P31/00 ,  A61K38/00 ,  C12N15/113

CPC分类号： A61K31/713 ,  A61P31/00 ,  A61K38/005 ,  C12N15/1137 ,  C12Y114/13039 ,  C12Y304/24086 ,  C12N2310/14

摘要： A method comprising administering, to a subject in need thereof, an effective amount of a nucleotide effective to disrupt one or more pathways leading to sepsis. The nucleotide may be a nitric oxide disruptor effective to decrease the expression of inducible nitric oxide synthase. The nitric oxide disrupter may comprise a polynucleotide strand exhibiting at least 70% sequence identity to one of Sequence ID No. 1 through Sequence ID No. 47. Additionally or alternatively, the nucleotide may be an α disintegrin and metalloproteinase (ADAM) enzyme inhibitor effective to decrease the expression of ADAM enzyme. The ADAM enzyme inhibitor may comprise a polynucleotide strand exhibiting at least 70% sequence identity to one of Sequence ID No. 48 through Sequence ID No. 56.

公开(公告)号：US11779669B2

公开(公告)日：2023-10-10

申请号：US17734296

申请日：2022-05-02

申请人： John Mansell

发明人： John Mansell

IPC分类号： A61L2/10 ,  A61B50/15

CPC分类号： A61L2/10 ,  A61B50/15 ,  A61L2202/16 ,  A61L2202/24

摘要： Embodiments of the disclosure include an uncovered ultraviolet light emitting panel for use in supporting instruments in an operating room. The panel fits inside an autoclave for sterilization and can be utilized without a sterile cover. In use, the panel irradiates surgical instruments and the nearby air continuously.

公开(公告)号：US20200276223A1

公开(公告)日：2020-09-03

申请号：US16647853

申请日：2018-09-20

申请人： John Mansell

发明人： John Mansell

IPC分类号： A61K31/713 ,  A61K38/00 ,  A61P31/00

摘要： A method comprising administering, to a subject in need thereof, an effective amount of a nucleotide effective to disrupt one or more pathways leading to sepsis. The nucleotide may be a nitric oxide disruptor effective to decrease the expression of inducible nitric oxide synthase. The nitric oxide disrupter may comprise a polynucleotide strand exhibiting at least 70% sequence identity to one of Sequence ID No.1 through Sequence ID No. 47. Additionally or alternatively, the nucleotide may be an α disintegrin and metalloproteinase (ADAM) enzyme inhibitor effective to decrease the expression of ADAM enzyme. The ADAM enzyme inhibitor may comprise a polynucleotide strand exhibiting at least 70% sequence identity to one of Sequence ID No. 48 through Sequence ID No. 56.

公开(公告)号：US07327907B2

公开(公告)日：2008-02-05

申请号：US10966751

申请日：2004-10-14

申请人： Sanan Shaibani ,  Joseph Krystkowiak ,  John Mansell ,  Akbar Arab-Sadenghabadi

发明人： Sanan Shaibani ,  Joseph Krystkowiak ,  John Mansell ,  Akbar Arab-Sadenghabadi

IPC分类号： G02B6/00 ,  G02B6/34

CPC分类号： G01H9/004 ,  G01V1/186 ,  G02B6/02057

摘要： Optical fibers, especially those having a core layer, a cladding layer over the core layer, FBG's formed in the core layer, the cladding layer, or both, a buffer layer over the cladding layer, and an outer jacketing layer.

摘要翻译： 光纤，特别是具有芯层，芯层上的包覆层，形成在芯层中的FBG，包层或两者，包层上的缓冲层，以及外护套层。

公开(公告)号：US07130506B2

公开(公告)日：2006-10-31

申请号：US11012398

申请日：2004-12-15

申请人： Sanan Shaibani ,  Joseph Krystkowiak ,  John Mansell ,  Akbar Arab-Sadeghabadi

发明人： Sanan Shaibani ,  Joseph Krystkowiak ,  John Mansell ,  Akbar Arab-Sadeghabadi

IPC分类号： G02B6/34

CPC分类号： G02B6/2932

摘要： Methods and apparatus for generating an optical waveform by distributing an input optical waveform among a plurality of environmentally isolated legs wherein each leg comprises a Bragg grating and contributes to the generated optical waveform by using the Bragg grating to reflect back at least a portion of light distributed to the leg.

公开(公告)号：US11351375B2

公开(公告)日：2022-06-07

申请号：US16490572

申请日：2018-03-02

申请人： John Mansell

发明人： John Mansell

IPC分类号： A61N1/36 ,  A61N1/05 ,  A61N1/365 ,  A61B8/12

摘要： Embodiments of the disclosure include systems and method for spinal cord stimulation. A spinal cord stimulator may comprise a pulse generator comprising electronic circuitry configured to generate output current; at least one lead in communication with the generator and configured to extend into the epidural space of a patient's spinal column; at least one electrode contact located proximate to a distal end of the at least one lead and configured to provide electric stimulation to a portion of a patient's spinal cord; and at least one sensor located along the at least one lead configured to determine a distance between the at least one lead and a surface of the patient's spinal cord, wherein the generator receives the determined distance, and wherein the generator is configured to adjust the stimulation provided by the at least one electrode contact based on the determined distance.

公开(公告)号：US20200276332A1

公开(公告)日：2020-09-03

申请号：US16605925

申请日：2018-04-19

申请人： John Mansell

发明人： John Mansell

IPC分类号： A61K48/00 ,  A61P23/00 ,  A61K45/06

摘要： A formulation comprising a gene expression modifier selected from the group consisting of an oligonucleotide having any of SEQ ID No.:1 through SEQ ID No.:55. A method of treating a subject diagnosed with a pain disorder includes introducing into the subject's cerebrospinal fluid a composition comprising an oligonucleotide that reduces the concentration of Substance P in the subject's cerebrospinal fluid. A method of treating a subject diagnosed with a pain disorder includes introducing to a plurality of tender points of a subject a gene expression modifier that reduces the concentration of calcitonin gene-related protein in the subject's cerebrospinal fluid.

公开(公告)号：US20200215212A1

公开(公告)日：2020-07-09

申请号：US16647819

申请日：2018-09-20

申请人： John Mansell

发明人： John Mansell

IPC分类号： A61L2/10

摘要： Embodiments of the disclosure include an uncovered ultraviolet light emitting panel for use in supporting instruments in an operating room. The panel fits inside an autoclave for sterilization and can be utilized without a sterile cover. In use, the panel irradiates surgical instruments and the nearby air continuously.

公开(公告)号：US07424186B2

公开(公告)日：2008-09-09

申请号：US11495974

申请日：2006-07-27

申请人： Akbar Arab-Sadeghabadi ,  Joseph Krystkowiak ,  John Mansell ,  Sanan Shaibani

发明人： Akbar Arab-Sadeghabadi ,  Joseph Krystkowiak ,  John Mansell ,  Sanan Shaibani

IPC分类号： G02B6/00 ,  G02B6/34

CPC分类号： G01D5/35303 ,  G01H9/004 ,  G01L11/025

摘要： A fiber optic acoustic transducer includes a mandrel having a first portion that preferably formed generally as a cylinder having a projection extending from one end. A grating collar also preferably formed in a generally cylindrical configuration. The grating collar has a passage extending therethrough so that it may mounted on the projection. An optical fiber has a sensor portion wound around the first portion of the mandrel and a second portion wound around the grating collar with a fiber Bragg grating being formed in the second portion of the optical fiber.

摘要翻译： 光纤声学换能器包括具有第一部分的心轴，该第一部分优选地大体上形成为具有从一端延伸的突出部的圆柱体。 光栅轴环也优选地形成为大致圆柱形的构造。 光栅轴环具有延伸穿过其中的通道，使得其可以安装在突起上。 光纤具有围绕心轴的第一部分缠绕的传感器部分，以及在光纤的第二部分中形成光纤布拉格光栅的第二部分。