公开(公告)号：US20140242060A1

公开(公告)日：2014-08-28

申请号：US14275259

申请日：2014-05-12

申请人： Aerase, Inc.

发明人： George GEORGIOU ,  Everett STONE

IPC分类号： C12N9/78

CPC分类号： A61K38/50 ,  A61K33/24 ,  A61K38/00 ,  A61K47/60 ,  A61K47/64 ,  C12N9/78 ,  C12Y305/03001

摘要： Compositions and methods for the treatment of cancer are described, and, more preferably, to the treatment of cancers that do not express, or are otherwise deficient in, argininosuccinate synthetase, with enzymes that deplete L-Arginine in serum. In one embodiment, the present invention contemplates an arginase protein, such as a human Arginase I protein, comprising at least one amino acid substitution and a metal cofactor, said protein comprising an increased catalytic activity when compared with a native human Arginase I.

摘要翻译： 描述了用于治疗癌症的组合物和方法，更优选地描述了在精氨酸琥珀酸合成酶中不表达或以其他方式缺乏的癌症的治疗，其中所述酶在血清中消耗L-精氨酸。 在一个实施方案中，本发明考虑了与天然人精氨酸酶I相比，包含至少一个氨基酸取代和金属辅因子的精氨酸酶蛋白，例如人精氨酸酶I蛋白，所述蛋白质包含增加的催化活性。