公开(公告)号：US20190071416A1

公开(公告)日：2019-03-07

申请号：US15767129

申请日：2016-10-10

Applicant: Agency For Science, Technology and Research

Inventor： Klement Jihao Foo ,  Anders Poulsen ,  Thomas Hugo Keller ,  Si Si Liew ,  Cheng San Brian Chia ,  Jin Yan Melgious Ang ,  Chuhul Huang

IPC: C07D401/06 ,  A61P35/00 ,  C07D401/14 ,  C07D413/14 ,  C07D417/14 ,  C07D471/08 ,  C07D405/14

Abstract: Compounds For Inhibition Of Cancer and Epigenesis. The present invention relates to quinolines and 5,6,7,8-tetrahydroacridines of the formula (I) wherein Z1, Z2, X, R1 to R8 and Y are defined as described in the specification, or a pharmaceutically acceptable form or prodrug thereof, that are inhibitors of methyl transferases such as protein lysine methyltransferases and more particularly SMYD3. The present invention also relates to the methods for their preparation, pharmaceutical compositions containing these compounds and uses of these compounds in the treatment of disorders/conditions/diseases involving, relating to or associated with enzymes having methyl transferase activities/functions and/or via unspecified/multi-targeted mechanisms.