公开(公告)号：US20240018221A1

公开(公告)日：2024-01-18

申请号：US18034289

申请日：2021-10-26

Applicant: Agency for Science, Technology and Research

Inventor： Wey Jia FONG ,  Boon Hwa CHOO ,  Mei Yee Vanessa DING ,  Chui Ping CHIN

IPC: C07K16/18 ,  A61P35/00

CPC classification number: C07K16/18 ,  A61K2039/505 ,  A61P35/00

Abstract: The invention relates generally to antigen-binding molecules that specifically bind to Myosin Heavy Chain 9 (MYH9) and uses thereof for the treatment of specific cancers, such as mast cell tumors. In one embodiment, the MYH9 is canine MYH9 and the antigen-binding molecule is an antibody. In another embodiment, the antigen-binding molecule is conjugated to a toxin, for the treatment of canine mast cell tumors.