公开(公告)号：US20240247317A1

公开(公告)日：2024-07-25

申请号：US18040066

申请日：2021-08-04

Applicant: Agency for Science, Technology and Research

Inventor： Camille Bleriot ,  Florent Ginhoux ,  Ankur Sharma

IPC: C12Q1/6886 ,  C12Q1/6874 ,  C12Q1/6881

CPC classification number: C12Q1/6886 ,  C12Q1/6881 ,  C12Q1/6874 ,  C12Q2600/158

Abstract: There is provided a method of characterising a macrophage in a tissue of a subject, wherein the method comprises determining an expression of one or more biomarkers in the macrophage, wherein the one or more biomarkers is selected from the group consisting of Folr2, SerpinaSi, Nid2, Slc27a6, SemaSa, Cdh13, Bcl6b, C6, Klf15, Marco, Cd209d, Tshz3, Bmpr1a, Tln2, Coro2b, Ackr2, 1110046J04Rik, Pcdhac2, Gm2253, Vsig4, Phactrt, NpM, CpneS, Angptl7, Gm26714, Auts2, Cxcl13, Sgce, 2900052N01 Rik, Cd209b, Timd4, Cd209g, Mrd (CD206), Spp1, Il22ra2, Gm24112, Gm23010, Ighv7-1, Gm23628, Gm24620, Gm23058, Arhgef37, Gad1-ps, Gm26397, Ighv2-5, Chil3, Mir1934, 1810012K08Rik, Ighv1-59, Gm14119, Gm19620 and Snord71. In one embodiment, the macrophage can be an embryo-derived macrophage and/or a long-lived tissue resident macrophage. In another embodiment, the macrophage can be a monocyte-derived macrophage. Also disclosed are methods of diagnosing a disease in a subject, methods of treating a disease, and kits for use thereof relating to a macrophage determined to express one or more of the said biomarkers.

公开(公告)号：US20240345084A1

公开(公告)日：2024-10-17

申请号：US18683027

申请日：2022-08-29

Applicant: Myriam Aouadi ,  Agency for Science, Technology and Research

Inventor： Myriam Aouadi ,  Camille Bleriot ,  Florent Ginhoux

IPC: G01N33/569

CPC classification number: G01N33/56972 ,  G01N2333/70596

Abstract: There is provided a method of detecting a population of macrophage in a sample comprising detecting and/or determining the expression of Cdh5 in the macrophage in the sample. Also disclosed is a kit for detecting and/or separating and/or depleting a population of a macrophage, a method of depleting a population of a macrophage, a method of improving the health of an obese and/or overweight subject, a method of determining the risk of obesity and/or a metabolic impairment related to obesity in a subject, and an animal model thereof.