公开(公告)号：US20220127565A1

公开(公告)日：2022-04-28

申请号：US17429132

申请日：2020-02-07

Applicant: Agency for Science, Technology and Research

Inventor： Yihua Loo ,  Chwee Aun Andrew Wan ,  Chih Urn Benjamin Tai

IPC: C12N5/0735 ,  C07K11/00

Abstract: There is provided a self-assembly amphiphilic peptide having the formula (I): XYZ (I), wherein X is a polar moiety at the N-terminus; X and Z each independently has between 1 to 4 residues of aliphatic amino acids or analogs or derivatives thereof, and wherein the average degree of hydrophobicity of the residues in block Z is more than the average degree of hydrophobicity of the residues in block Y. Disclosed are compositions and hydrogel comprising the peptide thereof. Also disclosed are methods of treatment for tissue regeneration, wound healing and methods of culture of stem cells, tissues and organoids.