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    "> METHODS FOR THE STIMULATION OF DENDRITIC CELL (DC) PRECURSOR POPULATION
    3.
    发明申请
    METHODS FOR THE STIMULATION OF DENDRITIC CELL (DC) PRECURSOR POPULATION "PRE-DC" AND THEIR USES THEREOF 有权

    公开(公告)号：US20210100897A1

    公开(公告)日：2021-04-08

    申请号：US16610461

    申请日：2018-05-03

    Applicant: AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH

    Inventor： Florent GINHOUX ,  Chi Ee Peter SEE

    IPC: A61K39/39 ,  A61K39/00 ,  A61K35/15 ,  C12N5/0784

    Abstract: The present invention relates to a method of treating or preventing an infection, a neoplastic disease or an immune-related disease in a subject in need thereof, the method comprising contacting a therapeutically effective or immuno-effective amount of an TLR9 agonist, specifically CpG oligodeoxynucleotide 2216 (CpG ODN), with a precursor dendritic cell (pre-DC), wherein the TLR9 agonist stimulates the pre-DC to secrete one or more cytokines such as TNF-alpha and IL-12p40, to thereby activate or increase the subject's immune response for treating or preventing the infection, the neoplastic disease or the immune-related disease. The present invention also relates to immunogenic or adjuvant compositions comprising the TLR9 agonist. A method of diagnosing a deficient immune system in a subject, comprising contacting a sample comprising pre-DC from the subject with one or more TLR 9 agonists and kits thereof are also disclosed.

    "> Methods For The Identification, Targeting And Isolation Of Human Dendritic Cell (DC) Precursors
    5.
    发明申请
    Methods For The Identification, Targeting And Isolation Of Human Dendritic Cell (DC) Precursors "Pre-DC" And Their Uses Thereof 审中-公开

    公开(公告)号：US20190324038A1

    公开(公告)日：2019-10-24

    申请号：US16329751

    申请日：2017-08-31

    Applicant: AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH

    Inventor： Florent GINHOUX ,  Chi Ee Peter SEE

    IPC: G01N33/569 ,  A61K35/15 ,  C07K16/28

    Abstract: Biomarkers for the detection and identification of a precursor of conventional dendritic cell (cDC) (pre-DC) and its cell subsets (pre-cDC1 or pre-cDC2), are defined, which include CD169, CD327, AXL, CD271, CD324 and combinations thereof for detecting pre-DCs. Methods for detecting a disease or condition, prognosis of an existing disease or condition comprising determining the number of pre-DC cells in sample from a subject as compared to control, as well as methods of treating a patient comprising administration of antibodies against CD169, CD327, AXL, CD271, CD324 and combinations thereof are also disclosed. In addition, an immunogenic composition comprising one or more binding molecules specific for one or more biomarkers or antigen of a target disease and/or one or more cells selected from the group consisting of early pre-DC, pre-cDC1 and pre-cDC2 are also disclosed for eliciting an immune response against an infectious disease or cancer.

    DIFFERENTIATION OF MACROPHAGES FROM PLURIPOTENT STEM CELLS
    6.
    发明申请
    DIFFERENTIATION OF MACROPHAGES FROM PLURIPOTENT STEM CELLS 审中-公开

    公开(公告)号：US20180010096A1

    公开(公告)日：2018-01-11

    申请号：US15544254

    申请日：2016-01-18

    Applicant: AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH

    Inventor： Hwei-In Shawn LIM ,  Tara HUBER ,  Florent GINHOUX

    IPC: C12N5/0786 ,  G01N33/50

    Abstract: The present invention relates to a method of culturing primitive-like macrophages from stem cells, a kit when used in the method thereof and uses of the primitive like macrophage for in-vitro disease models and for screening compounds for therapy. One embodied culture method comprises contacting and incubating embryonic stem cells or induced pluripotent stem cells with a serum-free culture media comprising a GSK3 inhibitor to differentiate stem cells into cells of the mesoderm lineage, followed by incubation with a culture media comprising Dickkopf-related protein 1 (DKK1) to differentiate the mesoderm into cells of hematopoietic lineage, maturing hematopoietic cells and incubating these cells with a culture media comprising M-CSF to drive differentiation into primitive-like macrophages. Another embodiment comprises incubating the stem cells with serum-free culture media comprising FGF2 and BMP4 to induce differentiation into cells of the mesoderm lineage, followed by incubating the cells with a culture media comprising FGF2, BMP4, Activin A and VEGF to differentiate the cells of the mesoderm lineage into cells of the hematopoietic cell lineage, maturing the cells of the hematopoietic cell lineage and lastly, incubating the matured hematopoietic cells with culture media comprising M-CSF to drive the differentiation of hematopoietic cells into primitive-like macrophages.

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