公开(公告)号：US11236128B2

公开(公告)日：2022-02-01

申请号：US16635472

申请日：2018-07-31

Applicant: Agency for Science, Technology and Research

Inventor： Tsz Ying Yuen ,  Charles William Johannes ,  Gerard Hilinski

IPC: C07K7/08 ,  C01G55/00 ,  C07K1/04 ,  C07K1/12

Abstract: Described herein is an operationally simple, one-pot solid-supported preparation of saturated stapled peptides. Following completion of ruthenium-catalysed metathesis, solid-phase transfer hydrogenation was achieved using triethylhydrosilane at elevated temperatures. The utility of the method has been demonstrated on 14- and 16-mer peptides to yield the corresponding cyclic a-helix stabilised stapled peptides.