公开(公告)号：US11091427B2

公开(公告)日：2021-08-17

申请号：US16497299

申请日：2018-03-23

Applicant: Agency for Science, Technology and Research

Inventor： Tsz Ying Yuen ,  Charles William Johannes ,  Greg Verdine

IPC: C07C227/12 ,  C07C229/48 ,  C07D265/32 ,  C07D265/34 ,  C07K5/08 ,  C07K7/06

Abstract: This invention relates to a method for producing an alkenyl 1-aminocyclopropane-1-carboxylic acid of Formula I wherein R1 is a protecting group, n is an integer between 1 and 10, and A and B are chiral centres such that when A is S, B is R and when A is R, B is S. The method comprises a stereoselective formation of the cyclopropane moiety by cycloaddition onto a double bond, in a molecule comprising a chiral template, Formula lc. Further provided is the use of Formula I in the production of stapled peptides.