公开(公告)号：US20210123021A1

公开(公告)日：2021-04-29

申请号：US16965197

申请日：2019-01-25

Applicant: Agency for Science, Technology and Research

Inventor： Lai Guan NG ,  Maximilien EVRARD ,  Immanuel Weng Han KWOK

IPC: C12N5/0787 ,  C07K14/705 ,  G01N33/50

Abstract: Disclosed is a method of characterising and/or separating neutrophils, the method comprises characterising and/or separating the neutrophils into a first population comprising proliferative neutrophils and a second population comprising mature neutrophils, according to the expression of CD101 on the neutrophils. Also disclosed are compositions comprising proliferative neutrophils that are CD10−CD101−, and methods of treatment, diagnostic or prognostic using neutrophils thereof, as well as kits for characterising and/or separating proliferative neutrophils based on the expression of CD101 or CD10. In a preferred embodiment, the population of neutrophils may be characterised as proliferative neutrophils if CD10−CD101−, as immature neutrophils if CD10−CD101+ and as mature neutrophils if CD10+CD101+.