公开(公告)号：US20220096604A1

公开(公告)日：2022-03-31

申请号：US17426756

申请日：2020-01-30

Applicant: AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH

Inventor： Wenn-Chyau LEE ,  Laurent RENIA

IPC: A61K38/36 ,  A61K38/18 ,  A61K31/366 ,  A61K31/357 ,  A61K31/4706 ,  A61K31/4709 ,  A61K31/506 ,  A61K31/635 ,  A61K31/65 ,  A61K31/137 ,  A61K31/155 ,  A61P33/06

Abstract: The invention relates to a composition comprising insulin growth factor binding protein 7 (IGFBP7) for treating malaria or reducing the phenomenon of IRB C-endothelial cytoadherence. The composition can further comprise Von Willebrand Factor (VWF) and/or thrombospondin-1 (TSP-1). The composition can also be used as an adjunct therapeutic agent alongside other anti-malarial drugs.

公开(公告)号：US20220187296A1

公开(公告)日：2022-06-16

申请号：US17117455

申请日：2020-12-10

Applicant: Agency for Science, Technology and Research

Inventor： Guillaume Robert CARISSIMO ,  Immanuel Kwok Weng HAN ,  Weili XU ,  Lisa Fong Poh NG ,  Laurent RENIA ,  Anis LARBI ,  Lai Guan NG

IPC: G01N33/569

Abstract: There is provided a method of evaluating risk of severe outcome of an infectious disease and/or an inflammatory disease in a patient, the method comprising: determining/measuring the number of one or more immune cells selected from the group consisting of VD2 T cells, CD8 T cells, and immature neutrophils in a sample obtained from the patient, wherein the patient has an enhanced risk of severe infectious disease and/or inflammatory disease outcome when: (i) the ratio of immature neutrophils to VD2 T cell is at least 2:1, and/or (ii) the ratio of immature neutrophils to CD8 T cell is at least 0.5:1. Also disclosed are method of treating a patient with a severe infectious disease and/or inflammatory disease and kit for use in methods thereof.

公开(公告)号：US20240369555A1

公开(公告)日：2024-11-07

申请号：US18773218

申请日：2024-07-15

Applicant: Agency for Science, Technology and Research

Inventor： Guillaume Robert CARISSIMO ,  Immanuel Kwok Weng HAN ,  Weili XU ,  Lisa Fong Poh NG ,  Laurent RENIA ,  Anis LARBI ,  Lai Guan NG

IPC: G01N33/569 ,  A61K49/00 ,  G01N33/50

Abstract: There is provided a method of evaluating risk of severe outcome of an infectious disease and/or an inflammatory disease in a patient, the method comprising: determining/measuring the number of one or more immune cells selected from the group consisting of VD2 T cells, CD8 T cells, and immature neutrophils in a sample obtained from the patient, wherein the patient has an enhanced risk of severe infectious disease and/or inflammatory disease outcome when: (i) the ratio of immature neutrophils to VD2 T cell is at least 2:1, and/or (ii) the ratio of immature neutrophils to CD8 T cell is at least 0.5:1. Also disclosed are method of treating a patient with a severe infectious disease and/or inflammatory disease and kit for use in methods thereof.