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公开(公告)号:US20200080081A1
公开(公告)日:2020-03-12
申请号:US16469603
申请日:2017-12-14
Applicant: Agency for Science, Technology and Research
Inventor: Kelvin Zhenwei SEE , Roger Sik Yin FOO
IPC: C12N15/113 , C12Q1/6881 , C12N15/115 , A01K67/027 , A61P9/00
Abstract: The invention relates to inhibitors of Sghrt and/or Gas5 lincRNAs, in particular to polynucleotides complementary to coding and non-coding sequences of said lincRNAs, and methods of producing said inhibitors. Also disclosed are the use of the afore agents to proliferate, regenerate or dedifferentiate a heart cell; methods for preventing and treating cardiac disease using the afore agents; and a prognostic or diagnostic assay to assess the regenerative or proliferative capacity of heart tissue before, after or during a cardiac treatment regimen, comprising determining the presence or amount of Sghrt and/or Gas5 lincRNAs. The present disclosure also relates to a method for screening for a therapeutic agent that can be used to treat or prevent a heart disorder, comprising analysing the functional expression and/or expression level of Sghrt and/or Gas5 lincRNAs in the presence and in the absence of the therapeutic agent.
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公开(公告)号:US20220227822A1
公开(公告)日:2022-07-21
申请号:US17430484
申请日:2020-02-12
Applicant: AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH
Inventor: Roger Sik Yin FOO , Dang Vinh DO
Abstract: The invention relates to an isolated polypeptide encoded by Sghrt and related uses. In addition, methods of assessing a heart function, treating impaired heart function by inhibiting Sghrt, identifying a potential drug for treating impaired heart function, and dedifferentiating and/or proliferating a heart cell by inhibiting Sghrt are claimed.
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