公开(公告)号：US20210155991A1

公开(公告)日：2021-05-27

申请号：US16977197

申请日：2019-03-01

Applicant: Agency for Science, Technology and Research

Inventor： Anders SKANDERUP ,  Guo YU ,  Sarah NG

IPC: C12Q1/6886 ,  C12Q1/6827

Abstract: There is provided a method of determining a risk of gastrointestinal cancer in a human subject, the method comprising: determining in a biological sample of the subject, whether mutation is present in at least one CTCF-binding sites (CBS) overlapping regions, or portions or flanking sequences thereof, or at least one non-CBS regions, or portions or flanking sequences thereof, wherein presence of mutation in at least one CBS overlapping regions, or portions or flanking sequences thereof, and/or at least one non-CBS regions, or portions or flanking sequences thereof, is indicative of a risk of gastrointestinal cancer in the subject. There are also provided a method of treating gastrointestinal cancer in a human subject and related kits.