公开(公告)号：US20220356210A1

公开(公告)日：2022-11-10

申请号：US17629338

申请日：2020-07-22

Applicant: Agency for Science, Technology and Research

Inventor： Yiyan YANG ,  Shaoqiong LIU ,  Pang Kern Jeremy TAN ,  Zhan Yuin ONG

IPC: C07K7/08 ,  C07K7/06 ,  A61P31/00

Abstract: Described herein are peptides that may self-assemble into hydrogels. The peptide comprises an amino acid sequence of alternating hydrophobic amino acids (X) and hydrophilic amino acids (Y), wherein each hydrophobic amino acid is independently selected from isoleucine (I), valine (V) and leucine (L), each hydrophilic amino acid is independently selected from arginine (R), lysine (K), glutamic acid (E), and aspartic acid (D), at least one hydrophilic amino acid is selected from arginine and lysine, at least one hydrophilic amino acid is selected from glutamic acid and aspartic acid, and the amino acid sequence contains at least 8 amino acids. Further described is a composition comprising a hydrogel formed of the peptides in a beta-sheet conformation and water or a dried form of the hydrogel. The hydrogel may be used for growing cells. In another aspect, a hybrid hydrogel prepared from IIK12 (IRIKIEIEIRIK) and IK8L (IRIKIRIK) may be used to treat a bacterial and/or fungal infection.

公开(公告)号：US20210145970A1

公开(公告)日：2021-05-20

申请号：US17130415

申请日：2020-12-22

Applicant: International Business Machines Corporation ,  Agency for Science, Technology, and Research (ASTAR)

Inventor： Dylan J. BODAY ,  Jeannette M. GARCIA ,  James L. HEDRICK ,  Nathaniel PARK ,  Rudy J. WOJTECKI ,  Yang CHUAN ,  Ashlynn LEE ,  Zhen Chang LIANG ,  Shaoqiong LIU ,  Yi Yan YANG

IPC: A61K47/34 ,  A61K9/00 ,  A61K9/107 ,  A61K38/00 ,  A61K31/7088 ,  C08G64/18 ,  A61K47/10

Abstract: A stimulus-responsive micellar carrier, methods that may be associated with making a stimulus-responsive micellar carrier, and methods that may be associated with using a stimulus-responsive micellar carrier are disclosed. The stimulus-responsive micellar carrier comprises a cargo molecule, and a linear block copolymer having a hydrophilic block connected to a hydrophobic block by a stimulus-responsive junction moiety. The micellar carrier can be supplied to a patient body for therapeutic purposes, such as the treatment of cancerous tissue. A method of preparing or obtaining a stimulus-responsive micellar carrier may include preparing a polyethylene glycol material having an acetal end group and then preparing a block copolymer by forming a reaction mixture including the polyethylene glycol material, a cyclic carbonate monomer, and a base.