公开(公告)号：US20230080224A1

公开(公告)日：2023-03-16

申请号：US17798025

申请日：2021-02-05

申请人： Agency for Science, Technology and Research

发明人： William SUN ,  Boon Ooi Patrick TAN ,  Huajing WANG ,  Thai Leong YAP ,  Shin Yee HONG ,  Cheng-I WANG ,  Ching-Wen HUANG ,  Shuet Theng LEE ,  Kah Fei WAN ,  Jian Duan Johnathan NG

IPC分类号： C07K16/40 ,  G01N33/573 ,  G01N33/574 ,  A61P35/00

摘要： The invention relates to antigen-binding molecules that specifically binds ALPPL2 and/or ALPP but not ALPL or ALPI. It also relates to a pharmaceutical composition, an immunoconjugate and a chimeric antigen receptor comprising said antigen-binding molecules. The invention also relates to methods for reducing the expression or activity of ALPPL2 in a cancer cell and methods of treating a cancer in a subject.