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公开(公告)号：US11013802B2
公开(公告)日：2021-05-25
申请号：US15834290
申请日：2017-12-07
申请人： Agenus Inc. , Ludwig Institute for Cancer Research Ltd , Memorial Sloan Kettering Cancer Center
发明人： Marc van Dijk , Cornelia Anne Mundt , Gerd Ritter , David Schaer , Jedd David Wolchok , Taha Merghoub , Nicholas Stuart Wilson , David Adam Savitsky , Mark Arthur Findeis , Dennis John Underwood , Jean-Marie Cuillerot , Igor Proscurshim , Olga Shebanova
IPC分类号： C07K16/28 , A61K39/395 , A61P11/00 , A61P35/04 , A61K39/00
摘要： The instant disclosure provides antibodies that specifically bind to CTLA-4 (e.g., human CTLA-4) and antagonize CTLA-4 function. Also provided are pharmaceutical compositions comprising these antibodies, nucleic acids encoding these antibodies, expression vectors and host cells for making these antibodies, and methods of treating a subject using these antibodies.
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公开(公告)号：US10479833B2
公开(公告)日：2019-11-19
申请号：US16165833
申请日：2018-10-19
申请人： Agenus Inc. , Ludwig Institute for Cancer Research Ltd , Memorial Sloan Kettering Cancer Center
发明人： Marc van Dijk , Cornelia Anne Mundt , Gerd Ritter , David Schaer , Jedd David Wolchok , Taha Merghoub , David Adam Savitsky , Nicholas Stuart Wilson
IPC分类号： C07K16/28 , A61K39/395 , A61K47/68 , A61K51/10 , A61K39/00
摘要： The instant disclosure provides antibodies that specifically bind to human CTLA-4 and antagonize CTLA-4 function. Also provided are pharmaceutical compositions comprising these antibodies, nucleic acids encoding these antibodies, expression vectors and host cells for making these antibodies, and methods of treating a subject using these antibodies.
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公开(公告)号：US20210205451A1
公开(公告)日：2021-07-08
申请号：US17121229
申请日：2020-12-14
申请人： Agenus Inc. , Ludwig Institute for Cancer Research Ltd , Memorial Sloan Kettering Cancer Center
发明人： Marc van Dijk , Cornelia Anne Mundt , Gerd Ritter , David Schaer , Jedd David Wolchok , Taha Merghoub , Nicholas Stuart Wilson , David Adam Savitsky , Mark Arthur Findeis , Dennis John Underwood , Jean-Marie Cuillerot , Igor Proscurshim , Olga Shebanova
IPC分类号： A61K39/395 , C07K16/28 , A61P11/00 , A61P35/04
摘要： The instant disclosure provides antibodies that specifically bind to CTLA-4 (e.g., human CTLA-4) and antagonize CTLA-4 function. Also provided are pharmaceutical compositions comprising these antibodies, nucleic acids encoding these antibodies, expression vectors and host cells for making these antibodies, and methods of treating a subject using these antibodies.
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公开(公告)号：US11267889B2
公开(公告)日：2022-03-08
申请号：US16858195
申请日：2020-04-24
申请人： Agenus Inc. , Ludwig Institute for Cancer Research Ltd , Memorial Sloan Kettering Cancer Center
发明人： Marc Van Dijk , Cornelia Anne Mundt , Gerd Ritter , David Schaer , Jedd David Wolchok , Taha Merghoub , David Adam Savitsky , Nicholas Stuart Wilson
摘要： The instant disclosure provides antibodies that specifically bind to human CTLA-4 and antagonize CTLA-4 function. Also provided are pharmaceutical compositions comprising these antibodies, nucleic acids encoding these antibodies, expression vectors and host cells for making these antibodies, and methods of treating a subject using these antibodies.
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公开(公告)号：US20180185481A1
公开(公告)日：2018-07-05
申请号：US15834290
申请日：2017-12-07
申请人： Agenus Inc. , Ludwig Institute for Cancer Research Ltd , Memorial Sloan Kettering Cancer Center
发明人： Marc van Dijk , Cornelia Anne Mundt , Gerd Ritter , David Schaer , Jedd David Wolchok , Taha Merghoub , Nicholas Stuart Wilson , David Adam Savitsky , Mark Arthur Findeis , Dennis John Underwood , Jean-Marie Cuillerot , Igor Proscurshim , Olga Shebanova
IPC分类号： A61K39/395 , A61P11/00 , A61P35/04
摘要： The instant disclosure provides antibodies that specifically bind to CTLA-4 (e.g., human CTLA-4) and antagonize CTLA-4 function. Also provided are pharmaceutical compositions comprising these antibodies, nucleic acids encoding these antibodies, expression vectors and host cells for making these antibodies, and methods of treating a subject using these antibodies.
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公开(公告)号：US20160368989A1
公开(公告)日：2016-12-22
申请号：US15166305
申请日：2016-05-27
申请人： Agenus Inc. , Ludwig Institute for Cancer Research Ltd , Memorial Sloan Kettering Cancer Center
发明人： Marc van Dijk , Cornelia Anne Mundt , Gerd Ritter , David Schaer , Jedd David Wolchok , Taha Merghoub , David Adam Savitsky , Mark Arthur Findeis , Nicholas Stuart Wilson
CPC分类号： C07K16/2818 , A61K47/6803 , A61K47/6849 , A61K51/1027 , A61K2039/505 , C07K16/283 , C07K2317/21 , C07K2317/33 , C07K2317/34 , C07K2317/41 , C07K2317/52 , C07K2317/56 , C07K2317/565 , C07K2317/567 , C07K2317/73 , C07K2317/76 , C07K2317/92
摘要： The instant disclosure provides antibodies that specifically bind to human CTLA-4 and antagonize CTLA-4 function. Also provided are pharmaceutical compositions comprising these antibodies, nucleic acids encoding these antibodies, expression vectors and host cells for making these antibodies, and methods of treating a subject using these antibodies.
摘要翻译： 本公开提供特异性结合人CTLA-4并拮抗CTLA-4功能的抗体。 还提供了包含这些抗体的药物组合物，编码这些抗体的核酸，用于制备这些抗体的表达载体和宿主细胞，以及使用这些抗体治疗受试者的方法。
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公开(公告)号：US11345755B2
公开(公告)日：2022-05-31
申请号：US16858193
申请日：2020-04-24
申请人： AGENUS INC. , LUDWIG INSTITUTE FOR CANCER RESEARCH LTD , MEMORIAL SLOAN KETTERING CANCER CENTER
发明人： Marc Van Dijk , Cornelia Anne Mundt , Gerd Ritter , Jedd David Wolchok , Taha Merghoub , Roberta Zappasodi , Rikke Bæk Holmgaard , David Schaer , David Adam Savitsky , Nicholas Stuart Wilson
IPC分类号： C07K16/28 , A61K39/395 , A61P35/00 , A61K39/00
摘要： The instant disclosure provides antibodies that specifically bind to human PD-1 and antagonize PD-1 function. Also provided are pharmaceutical compositions comprising these antibodies, nucleic acids encoding these antibodies, expression vectors and host cells for making these antibodies, and methods of treating a subject using these antibodies.
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公开(公告)号：US10912831B1
公开(公告)日：2021-02-09
申请号：US17030650
申请日：2020-09-24
申请人： Agenus Inc. , Ludwig Institute for Cancer Research Ltd , Memorial Sloan Kettering Cancer Center
发明人： Marc van Dijk , Cornelia Anne Mundt , Gerd Ritter , David Schaer , Jedd David Wolchok , Taha Merghoub , Nicholas Stuart Wilson , David Adam Savitsky , Mark Arthur Findeis , Dennis John Underwood , Jean-Marie Cuillerot , Igor Proscurshim , Olga Shebanova
IPC分类号： A61K39/395 , C07K16/28 , A61P11/00 , A61P35/04 , A61K39/00
摘要： The instant disclosure provides antibodies that specifically bind to CTLA-4 (e.g., human CTLA-4) and antagonize CTLA-4 function. Also provided are pharmaceutical compositions comprising these antibodies, nucleic acids encoding these antibodies, expression vectors and host cells for making these antibodies, and methods of treating a subject using these antibodies.
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公开(公告)号：US10450373B2
公开(公告)日：2019-10-22
申请号：US16399262
申请日：2019-04-30
申请人： AGENUS INC. , LUDWIG INSTITUTE FOR CANCER RESEARCH LTD , MEMORIAL SLOAN KETTERING CANCER CENTER
发明人： Marc Van Dijk , Cornelia Anne Mundt , Gerd Ritter , Jedd David Wolchok , Taha Merghoub , Roberta Zappasodi , Rikke Baek Holmgaard , David Schaer , David Adam Savitsky , Nicholas Stuart Wilson
IPC分类号： C07K16/28 , A61K39/395 , A61K39/00
摘要： The instant disclosure provides antibodies that specifically bind to human PD-1 and antagonize PD-1 function. Also provided are pharmaceutical compositions comprising these antibodies, nucleic acids encoding these antibodies, expression vectors and host cells for making these antibodies, and methods of treating a subject using these antibodies.
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公开(公告)号：US10323091B2
公开(公告)日：2019-06-18
申请号：US15254315
申请日：2016-09-01
申请人： Agenus Inc. , Ludwig Institute for Cancer Research Ltd , Memorial Sloan Kettering Cancer Center
发明人： Marc van Dijk , Nicholas Stuart Wilson , Cornelia Anne Mundt , Gerd Ritter , Jedd David Wolchok , Taha Merghoub , Roberta Zappasodi , Rikke Bæk Holmgaard , David Schaer , David Adam Savitsky
IPC分类号： C07K16/28 , A61K39/395 , A61K39/00
摘要： The instant disclosure provides antibodies that specifically bind to human PD-1 and antagonize PD-1 function. Also provided are pharmaceutical compositions comprising these antibodies, nucleic acids encoding these antibodies, expression vectors and host cells for making these antibodies, and methods of treating a subject using these antibodies.
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